Improving the cytotoxicity of immunotoxins by reducing the affinity of the antibody in acidic pH

Improving the cytotoxicity of immunotoxins by reducing the affinity of the antibody in acidic pH

Abstract Background Immunotoxins are antibody-toxin conjugates that bind to surface antigens and exert effective cytotoxic activity after internalization into tumor cells. Immunotoxins exhibit effective cytotoxicity and have been approved by the FDA to treat multiple hematological malignancies, such...

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Bibliographic Details
Main Authors: Xiaoyu Liu, Qingqing Tan, Jiaqi Wen, Xufei Wang, Gang Yang, Yuxiao Li, Ming Lu, Wei Ye, Anfeng Si, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Mei Zhang, Tao Jiang, Wei Gao
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Translational Medicine
Subjects:
Immunotoxin
Low pH-responsive antigen binding
Lysosomal degradation
Toxin release
Glypican-3
Online Access:https://doi.org/10.1186/s12967-023-04210-7

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