Association Between H. pylori Infection and Colorectal Polyps: A Meta-Analysis of Observational Studies
BackgroundIt has been suggested that Helicobacter pylori (H. pylori) infection is associated with hypergastrinemia and proliferation of colorectal mucosa via direct stimulation, dysbiosis of the gut microbiome, and changes in the gut microbiome, all of which may lead to the formation of colorectal p...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.706036/full |
| _version_ | 1798025369549275136 |
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| author | Depeng Lu Mingyu Wang Xiquan Ke Qiangwu Wang Jianchao Wang Dapeng Li Meng Wang Qizhi Wang |
| author_facet | Depeng Lu Mingyu Wang Xiquan Ke Qiangwu Wang Jianchao Wang Dapeng Li Meng Wang Qizhi Wang |
| author_sort | Depeng Lu |
| collection | DOAJ |
| description | BackgroundIt has been suggested that Helicobacter pylori (H. pylori) infection is associated with hypergastrinemia and proliferation of colorectal mucosa via direct stimulation, dysbiosis of the gut microbiome, and changes in the gut microbiome, all of which may lead to the formation of colorectal polyps. However, the consensus remains lacking regarding whether H. pylori infection is independently associated with colorectal polyps and whether the association differs according to histological type of colorectal polyps. To summarize the current evidence regarding the relationship between H. pylori infection and colorectal polyps, we conducted a meta-analysis of related observational studies according to the histological types of colorectal polyps.MethodsObservational studies investigating the association between H. pylori infection and colorectal polyps using multivariate analyses were included by search of PubMed, Embase, and Web of Science. A random-effects model was adopted to combine the results.ResultsSeventeen studies that include 322,395 participants were analyzed. It was shown that H. pylori infection was independently associated with overall colorectal polyps (odds ratio [OR]: 1.67, 95% CI: 1.24–2.24, p < 0.001; I2 = 73%). According to the histological type of colorectal polyps, H. pylori infection was independently associated with adenomatous polyps (APs; OR: 1.71, 95% CI: 1.47–1.99, p < 0.001; I2 = 86%), advanced APs (OR: 2.06, 95% CI: 1.56–2.73, p < 0.001; I2 = 0%), and hyperplastic polyps (HPs; OR: 1.54, 95% CI: 1.02–2.30, p = 0.04; I2 = 78%). Evidence based on only one study showed that H. pylori infection was not associated with sessile serrated polyps (SSPs; OR: 1.00, 95% CI: 0.93–1.07, p = 0.99).ConclusionsCurrent evidence from case-control and cross-sectional studies suggested that H. pylori infection was independently associated with colorectal APs, advanced APs, and HPs, but not with SSPs. These findings suggested H. pylori infection may be a possible risk factor of colorectal polyp, which is important for the prevention of colorectal polyp in the adult population. |
| first_indexed | 2024-04-11T18:17:42Z |
| format | Article |
| id | doaj.art-8280ba05a43946c784cf8016c1c8665a |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T18:17:42Z |
| publishDate | 2022-01-01 |
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| series | Frontiers in Medicine |
| spelling | doaj.art-8280ba05a43946c784cf8016c1c8665a2022-12-22T04:09:50ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01810.3389/fmed.2021.706036706036Association Between H. pylori Infection and Colorectal Polyps: A Meta-Analysis of Observational StudiesDepeng Lu0Mingyu Wang1Xiquan Ke2Qiangwu Wang3Jianchao Wang4Dapeng Li5Meng Wang6Qizhi Wang7Department of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, ChinaDepartment of Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, ChinaBackgroundIt has been suggested that Helicobacter pylori (H. pylori) infection is associated with hypergastrinemia and proliferation of colorectal mucosa via direct stimulation, dysbiosis of the gut microbiome, and changes in the gut microbiome, all of which may lead to the formation of colorectal polyps. However, the consensus remains lacking regarding whether H. pylori infection is independently associated with colorectal polyps and whether the association differs according to histological type of colorectal polyps. To summarize the current evidence regarding the relationship between H. pylori infection and colorectal polyps, we conducted a meta-analysis of related observational studies according to the histological types of colorectal polyps.MethodsObservational studies investigating the association between H. pylori infection and colorectal polyps using multivariate analyses were included by search of PubMed, Embase, and Web of Science. A random-effects model was adopted to combine the results.ResultsSeventeen studies that include 322,395 participants were analyzed. It was shown that H. pylori infection was independently associated with overall colorectal polyps (odds ratio [OR]: 1.67, 95% CI: 1.24–2.24, p < 0.001; I2 = 73%). According to the histological type of colorectal polyps, H. pylori infection was independently associated with adenomatous polyps (APs; OR: 1.71, 95% CI: 1.47–1.99, p < 0.001; I2 = 86%), advanced APs (OR: 2.06, 95% CI: 1.56–2.73, p < 0.001; I2 = 0%), and hyperplastic polyps (HPs; OR: 1.54, 95% CI: 1.02–2.30, p = 0.04; I2 = 78%). Evidence based on only one study showed that H. pylori infection was not associated with sessile serrated polyps (SSPs; OR: 1.00, 95% CI: 0.93–1.07, p = 0.99).ConclusionsCurrent evidence from case-control and cross-sectional studies suggested that H. pylori infection was independently associated with colorectal APs, advanced APs, and HPs, but not with SSPs. These findings suggested H. pylori infection may be a possible risk factor of colorectal polyp, which is important for the prevention of colorectal polyp in the adult population.https://www.frontiersin.org/articles/10.3389/fmed.2021.706036/fullH. pylori infectioncolorectal polypsadenomatous polypshyperplastic polypsmeta-analysis |
| spellingShingle | Depeng Lu Mingyu Wang Xiquan Ke Qiangwu Wang Jianchao Wang Dapeng Li Meng Wang Qizhi Wang Association Between H. pylori Infection and Colorectal Polyps: A Meta-Analysis of Observational Studies Frontiers in Medicine H. pylori infection colorectal polyps adenomatous polyps hyperplastic polyps meta-analysis |
| title | Association Between H. pylori Infection and Colorectal Polyps: A Meta-Analysis of Observational Studies |
| title_full | Association Between H. pylori Infection and Colorectal Polyps: A Meta-Analysis of Observational Studies |
| title_fullStr | Association Between H. pylori Infection and Colorectal Polyps: A Meta-Analysis of Observational Studies |
| title_full_unstemmed | Association Between H. pylori Infection and Colorectal Polyps: A Meta-Analysis of Observational Studies |
| title_short | Association Between H. pylori Infection and Colorectal Polyps: A Meta-Analysis of Observational Studies |
| title_sort | association between h pylori infection and colorectal polyps a meta analysis of observational studies |
| topic | H. pylori infection colorectal polyps adenomatous polyps hyperplastic polyps meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.706036/full |
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