Congenital Defects in Actin Dynamics of Germinal Center B Cells
The germinal center (GC) is a transient anatomical structure formed during the adaptive immune response that leads to antibody affinity maturation and serological memory. Recent works using two-photon microscopy reveals that the GC is a highly dynamic structure and GC B cells are highly motile. An e...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00296/full |
| _version_ | 1811299101334044672 |
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| author | Minghui He Lisa S. Westerberg |
| author_facet | Minghui He Lisa S. Westerberg |
| author_sort | Minghui He |
| collection | DOAJ |
| description | The germinal center (GC) is a transient anatomical structure formed during the adaptive immune response that leads to antibody affinity maturation and serological memory. Recent works using two-photon microscopy reveals that the GC is a highly dynamic structure and GC B cells are highly motile. An efficient selection of high affinity B cells clones within the GC crucially relies on the interplay of proliferation, genome editing, cell-cell interaction, and migration. All these processes require actin cytoskeleton rearrangement to be well-coordinated. Dysregulated actin dynamics may impede on multiple stages during B cell affinity maturation, which could lead to aberrant GC response and result in autoimmunity and B cell malignancy. This review mainly focuses on the recent works that investigate the role of actin regulators during the GC response. |
| first_indexed | 2024-04-13T06:31:05Z |
| format | Article |
| id | doaj.art-828581117dc447908fa9e9c7f772c9d8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T06:31:05Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-828581117dc447908fa9e9c7f772c9d82022-12-22T02:58:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-03-011010.3389/fimmu.2019.00296436745Congenital Defects in Actin Dynamics of Germinal Center B CellsMinghui HeLisa S. WesterbergThe germinal center (GC) is a transient anatomical structure formed during the adaptive immune response that leads to antibody affinity maturation and serological memory. Recent works using two-photon microscopy reveals that the GC is a highly dynamic structure and GC B cells are highly motile. An efficient selection of high affinity B cells clones within the GC crucially relies on the interplay of proliferation, genome editing, cell-cell interaction, and migration. All these processes require actin cytoskeleton rearrangement to be well-coordinated. Dysregulated actin dynamics may impede on multiple stages during B cell affinity maturation, which could lead to aberrant GC response and result in autoimmunity and B cell malignancy. This review mainly focuses on the recent works that investigate the role of actin regulators during the GC response.https://www.frontiersin.org/article/10.3389/fimmu.2019.00296/fullgerminal centerB cell receptorimmune synapseactin cytoskeletonantibodies |
| spellingShingle | Minghui He Lisa S. Westerberg Congenital Defects in Actin Dynamics of Germinal Center B Cells Frontiers in Immunology germinal center B cell receptor immune synapse actin cytoskeleton antibodies |
| title | Congenital Defects in Actin Dynamics of Germinal Center B Cells |
| title_full | Congenital Defects in Actin Dynamics of Germinal Center B Cells |
| title_fullStr | Congenital Defects in Actin Dynamics of Germinal Center B Cells |
| title_full_unstemmed | Congenital Defects in Actin Dynamics of Germinal Center B Cells |
| title_short | Congenital Defects in Actin Dynamics of Germinal Center B Cells |
| title_sort | congenital defects in actin dynamics of germinal center b cells |
| topic | germinal center B cell receptor immune synapse actin cytoskeleton antibodies |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00296/full |
| work_keys_str_mv | AT minghuihe congenitaldefectsinactindynamicsofgerminalcenterbcells AT lisaswesterberg congenitaldefectsinactindynamicsofgerminalcenterbcells |