Advances in research based on antibody-cell conjugation
Antibody-cell conjugation (ACC) technology is a new research direction in medicine and biotechnology in recent years. The concept of ACC was proposed by Hsiao et al. and developed into a viable cell therapy technology, which refers to the cells with specific functions. Such as natural killer cells (...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1310130/full |
| _version_ | 1827584473102811136 |
|---|---|
| author | Xiaoxuan Ma Jian Jiang Xiaoye An Wanting Zu Chi Ma Zhuo Zhang Yaci Lu Lijing Zhao Lisheng Wang |
| author_facet | Xiaoxuan Ma Jian Jiang Xiaoye An Wanting Zu Chi Ma Zhuo Zhang Yaci Lu Lijing Zhao Lisheng Wang |
| author_sort | Xiaoxuan Ma |
| collection | DOAJ |
| description | Antibody-cell conjugation (ACC) technology is a new research direction in medicine and biotechnology in recent years. The concept of ACC was proposed by Hsiao et al. and developed into a viable cell therapy technology, which refers to the cells with specific functions. Such as natural killer cells (NK cells), cytokine induced killer cells (CIK) and other immune cells and monoclonal antibodies through the linker together formed conjugate. ACC directly modifies specific antibodies on the cell surface through a simple and effective chemical coupling method to enable cells to have new functions. ACC has been developed for the treatment of various diseases, including cancers of the blood system and solid tumors. This paper reviews the current ACC construction methods, challenges and future development directions. |
| first_indexed | 2024-03-08T23:29:55Z |
| format | Article |
| id | doaj.art-828624176e3e4a83958b5db95bb101ac |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T23:29:55Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-828624176e3e4a83958b5db95bb101ac2023-12-14T14:52:47ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.13101301310130Advances in research based on antibody-cell conjugationXiaoxuan Ma0Jian Jiang1Xiaoye An2Wanting Zu3Chi Ma4Zhuo Zhang5Yaci Lu6Lijing Zhao7Lisheng Wang8Department of Rehabilitation, School of Nursing, Jilin University, Changchun, ChinaDepartment of Rehabilitation, School of Nursing, Jilin University, Changchun, ChinaDepartment of Pharmacy, Tacheng People's Hospital, Tacheng City, Xinjiang Uygur Autonomous Region, ChinaDepartment of Rehabilitation, School of Nursing, Jilin University, Changchun, ChinaDepartment of Rehabilitation, School of Nursing, Jilin University, Changchun, ChinaDepartment of Rehabilitation, School of Nursing, Jilin University, Changchun, ChinaDepartment of Rehabilitation, School of Nursing, Jilin University, Changchun, ChinaDepartment of Rehabilitation, School of Nursing, Jilin University, Changchun, ChinaDepartment of Rehabilitation, School of Nursing, Jilin University, Changchun, ChinaAntibody-cell conjugation (ACC) technology is a new research direction in medicine and biotechnology in recent years. The concept of ACC was proposed by Hsiao et al. and developed into a viable cell therapy technology, which refers to the cells with specific functions. Such as natural killer cells (NK cells), cytokine induced killer cells (CIK) and other immune cells and monoclonal antibodies through the linker together formed conjugate. ACC directly modifies specific antibodies on the cell surface through a simple and effective chemical coupling method to enable cells to have new functions. ACC has been developed for the treatment of various diseases, including cancers of the blood system and solid tumors. This paper reviews the current ACC construction methods, challenges and future development directions.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1310130/fullantibody-cell conjugationcancer therapycancer cell therapymonoclonal antibodytumor targeting therapy |
| spellingShingle | Xiaoxuan Ma Jian Jiang Xiaoye An Wanting Zu Chi Ma Zhuo Zhang Yaci Lu Lijing Zhao Lisheng Wang Advances in research based on antibody-cell conjugation Frontiers in Immunology antibody-cell conjugation cancer therapy cancer cell therapy monoclonal antibody tumor targeting therapy |
| title | Advances in research based on antibody-cell conjugation |
| title_full | Advances in research based on antibody-cell conjugation |
| title_fullStr | Advances in research based on antibody-cell conjugation |
| title_full_unstemmed | Advances in research based on antibody-cell conjugation |
| title_short | Advances in research based on antibody-cell conjugation |
| title_sort | advances in research based on antibody cell conjugation |
| topic | antibody-cell conjugation cancer therapy cancer cell therapy monoclonal antibody tumor targeting therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1310130/full |
| work_keys_str_mv | AT xiaoxuanma advancesinresearchbasedonantibodycellconjugation AT jianjiang advancesinresearchbasedonantibodycellconjugation AT xiaoyean advancesinresearchbasedonantibodycellconjugation AT wantingzu advancesinresearchbasedonantibodycellconjugation AT chima advancesinresearchbasedonantibodycellconjugation AT zhuozhang advancesinresearchbasedonantibodycellconjugation AT yacilu advancesinresearchbasedonantibodycellconjugation AT lijingzhao advancesinresearchbasedonantibodycellconjugation AT lishengwang advancesinresearchbasedonantibodycellconjugation |