Towards Response ADAptive Radiotherapy for organ preservation for intermediate-risk rectal cancer (preRADAR): protocol of a phase I dose-escalation trial

Towards Response ADAptive Radiotherapy for organ preservation for intermediate-risk rectal cancer (preRADAR): protocol of a phase I dose-escalation trial

Introduction Organ preservation is associated with superior functional outcome and quality of life (QoL) compared with total mesorectal excision (TME) for rectal cancer. Only 10% of patients are eligible for organ preservation following short-course radiotherapy (SCRT, 25 Gy in five fractions) and a...

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Main Authors: Miangela M Lacle, Sjoerd G Elias, Leon M G Moons, Helena M Verkooijen, Manon N G J A Braat, Myriam Chalabi, Corrie A M Marijnen, Femke P Peters, Brechtje A Grotenhuis, Miriam Koopman, Petur Snaebjornsson, Esther Consten, Wilhelmina M U van Grevenstein, Maaike E Verweij, Max D Tanaka, Chavelli M Kensen, Uulke A van der Heide, Tomas Janssen, Tineke Vijlbrief, Monique Maas, Inge L Huibregtse, Remond Fijneman, Apollo Pronk, Anke B Smits, Joost T Heikens, Hidde Eijkelenkamp, Maartje M C Schoenmakers, Gert J Meijer, Martijn Intven
Format: Article
Language:English
Published: BMJ Publishing Group 2023-06-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/6/e065010.full

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