Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile
Introduction: Rhinosporidiosis is an enigmatic disease with many unsolved queries right from taxonomy to treatment. This study has been done to understand the disease characteristics with a peek into the lesser known immunological aspects of it by studying the changes in levels of certain primarily...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-09-01
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| Series: | Iranian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | https://ijorl.mums.ac.ir/article_22955_7ef5474cb0f5726c404eacd3576f64ac.pdf |
| _version_ | 1797673797087657984 |
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| author | Megha Chandran Rupa Mehta NITIN NAGARKAR Anudita Bhargava Eli Mohapatra Saroj Pati |
| author_facet | Megha Chandran Rupa Mehta NITIN NAGARKAR Anudita Bhargava Eli Mohapatra Saroj Pati |
| author_sort | Megha Chandran |
| collection | DOAJ |
| description | Introduction: Rhinosporidiosis is an enigmatic disease with many unsolved queries right from taxonomy to treatment. This study has been done to understand the disease characteristics with a peek into the lesser known immunological aspects of it by studying the changes in levels of certain primarily cell-mediated immunity (CMI)-specific cytokines in rhinosporidiosis patients.Materials and Methods:A prospective observational study was performed. Detailed epidemiological and clinicoradiological assessment was done along with selected inflammatory and immunological markers. The tests for immunological parameters were done by ELISA and CLIA and data were compiled and analyzed using appropriate statistics.Results:Disease showed male predominance and all patients gave a universal pond bathing history. Majority patients had O+ve blood group. Right side was affected most with nasal obstruction being commonest symptom. Nasal cavity was involved in majority of cases with inferior turbinate and meatus being sites of maximum occurrence and attachment. Nasopharynx, oropharynx were other involved sites. Extra-nasal sites included skin and parotid gland. Endoscopic and CECT findings were similar and confirmed intraoperatively. Tests for inflammatory markers showed no significant change in patients. Immunological markers -IL-6, TNF-beta- levels showed significant increase though no such increase was found with IFN-gamma levels.Conclusion:Rhinosporidiosis has a definite epidemiological and clinical-radiological profile. A clear association with exposure to contaminated water is present which could not be further associated with disease duration or recurrence. The immunological profile needs to be further investigated upon since it remains quite elusive. |
| first_indexed | 2024-03-11T21:50:34Z |
| format | Article |
| id | doaj.art-828863a6e9d842458b1e593f24be937c |
| institution | Directory Open Access Journal |
| issn | 2251-7251 2251-726X |
| language | English |
| last_indexed | 2024-03-11T21:50:34Z |
| publishDate | 2023-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Otorhinolaryngology |
| spelling | doaj.art-828863a6e9d842458b1e593f24be937c2023-09-26T09:02:36ZengMashhad University of Medical SciencesIranian Journal of Otorhinolaryngology2251-72512251-726X2023-09-0135525526210.22038/ijorl.2023.68378.333122955Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological ProfileMegha Chandran0Rupa Mehta1NITIN NAGARKAR2Anudita Bhargava3Eli Mohapatra4Saroj Pati5MS ENT, All India Institute of Medical Sciences RaipurASSOCIATE PROFESOR , AIIMS RAIPURPROFESSOR AND HOD, DEPARTMENT OF ENT & HNS, AIIMS RAIPUR (CHHATTISGARH), INDIAProfessor and Head, Department of Microbiology, AIIMS, RaipurProfessor and Head, Department of Biochemistry, AIIMS RaipurAssociate Professor, Department of Radiology, AIIMS RaipurIntroduction: Rhinosporidiosis is an enigmatic disease with many unsolved queries right from taxonomy to treatment. This study has been done to understand the disease characteristics with a peek into the lesser known immunological aspects of it by studying the changes in levels of certain primarily cell-mediated immunity (CMI)-specific cytokines in rhinosporidiosis patients.Materials and Methods:A prospective observational study was performed. Detailed epidemiological and clinicoradiological assessment was done along with selected inflammatory and immunological markers. The tests for immunological parameters were done by ELISA and CLIA and data were compiled and analyzed using appropriate statistics.Results:Disease showed male predominance and all patients gave a universal pond bathing history. Majority patients had O+ve blood group. Right side was affected most with nasal obstruction being commonest symptom. Nasal cavity was involved in majority of cases with inferior turbinate and meatus being sites of maximum occurrence and attachment. Nasopharynx, oropharynx were other involved sites. Extra-nasal sites included skin and parotid gland. Endoscopic and CECT findings were similar and confirmed intraoperatively. Tests for inflammatory markers showed no significant change in patients. Immunological markers -IL-6, TNF-beta- levels showed significant increase though no such increase was found with IFN-gamma levels.Conclusion:Rhinosporidiosis has a definite epidemiological and clinical-radiological profile. A clear association with exposure to contaminated water is present which could not be further associated with disease duration or recurrence. The immunological profile needs to be further investigated upon since it remains quite elusive.https://ijorl.mums.ac.ir/article_22955_7ef5474cb0f5726c404eacd3576f64ac.pdfendemiccell-mediated immunitycytokinesil-6tnf-betaifn-gamma |
| spellingShingle | Megha Chandran Rupa Mehta NITIN NAGARKAR Anudita Bhargava Eli Mohapatra Saroj Pati Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile Iranian Journal of Otorhinolaryngology endemic cell-mediated immunity cytokines il-6 tnf-beta ifn-gamma |
| title | Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile |
| title_full | Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile |
| title_fullStr | Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile |
| title_full_unstemmed | Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile |
| title_short | Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile |
| title_sort | rhinosporidiosis epidemiological clinicoradiological immunological profile |
| topic | endemic cell-mediated immunity cytokines il-6 tnf-beta ifn-gamma |
| url | https://ijorl.mums.ac.ir/article_22955_7ef5474cb0f5726c404eacd3576f64ac.pdf |
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