The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers’ Pneumoconiosis
Evidence suggests that exposure to coal dust increases immunoglobulin concentration. However, there is a paucity of data reporting immunoglobulin G (IgG) subclass in coal workers’ pneumoconiosis (CWP). Therefore, this study intended to evaluate potential diagnostic biomarkers for the disease. CWP pa...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2023/9233386 |
| _version_ | 1797866174455742464 |
|---|---|
| author | Zhao-Guo Li Bai-Cun Li Zhi-Wei Li Hui-Yuan Hu Xia Ma Hong Cao Zhi-Hua Yu Hua-Ping Dai Jing Wang Chen Wang |
| author_facet | Zhao-Guo Li Bai-Cun Li Zhi-Wei Li Hui-Yuan Hu Xia Ma Hong Cao Zhi-Hua Yu Hua-Ping Dai Jing Wang Chen Wang |
| author_sort | Zhao-Guo Li |
| collection | DOAJ |
| description | Evidence suggests that exposure to coal dust increases immunoglobulin concentration. However, there is a paucity of data reporting immunoglobulin G (IgG) subclass in coal workers’ pneumoconiosis (CWP). Therefore, this study intended to evaluate potential diagnostic biomarkers for the disease. CWP patients, dust-exposed workers without pneumoconiosis (DEW), and matched healthy controls (HCs) presented to the General Hospital of Datong Coal Mining Group and Occupational Disease Prevention and Treatment Hospital of Datong Coal Mining Group between May 2019 and September 2019 were recruited. The serum immunoglobulin concentration was determined by the multiplex immunoassay technique. Totally, 104 CWP patients, 109 DEWs, and 74 HCs were enrolled. Serum levels of IgG1, IgG2, IgM, and IgA were elevated in CWPs compared with those in DEWs and HCs (P<0.05). The order of diagnostic accuracy between CWPs and DEWs depicted by the receiver operating characteristic (ROC) curve was IgG2, IgM, IgG1, IgG3, and IgA. Significantly higher IgG1/IgG3 and IgG2/IgG3 ratios were observed in the CWP group than in DEW and HC groups. Based on the IgG2/IgG3 ratio, the area under the ROC curve between CWP and DEW was 0.785 (95% CI 0.723-0.838), with a sensitivity of 73.1% and a specificity of 73.4%. Our findings suggest that IgG1, IgG2, IgM, and IgA are higher in the CWPs than DEWs and HCs. The IgG2/IgG3 ratio provides a viable alternative for the diagnosis of CWP. |
| first_indexed | 2024-04-09T23:19:46Z |
| format | Article |
| id | doaj.art-828906b3d9f2469fbff26f569119bd49 |
| institution | Directory Open Access Journal |
| issn | 2314-7156 |
| language | English |
| last_indexed | 2024-04-09T23:19:46Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj.art-828906b3d9f2469fbff26f569119bd492023-03-22T00:00:12ZengHindawi LimitedJournal of Immunology Research2314-71562023-01-01202310.1155/2023/9233386The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers’ PneumoconiosisZhao-Guo Li0Bai-Cun Li1Zhi-Wei Li2Hui-Yuan Hu3Xia Ma4Hong Cao5Zhi-Hua Yu6Hua-Ping Dai7Jing Wang8Chen Wang9Department of RespiratoryInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesDepartment of Pulmonary and Critical Care MedicineOccupational Disease Prevention and treatment Hospital of Datong Coal Mine Group Co.Occupational Disease Prevention and treatment Hospital of Datong Coal Mine Group Co.Department of Pulmonary and Critical Care MedicineInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesDepartment of RespiratoryEvidence suggests that exposure to coal dust increases immunoglobulin concentration. However, there is a paucity of data reporting immunoglobulin G (IgG) subclass in coal workers’ pneumoconiosis (CWP). Therefore, this study intended to evaluate potential diagnostic biomarkers for the disease. CWP patients, dust-exposed workers without pneumoconiosis (DEW), and matched healthy controls (HCs) presented to the General Hospital of Datong Coal Mining Group and Occupational Disease Prevention and Treatment Hospital of Datong Coal Mining Group between May 2019 and September 2019 were recruited. The serum immunoglobulin concentration was determined by the multiplex immunoassay technique. Totally, 104 CWP patients, 109 DEWs, and 74 HCs were enrolled. Serum levels of IgG1, IgG2, IgM, and IgA were elevated in CWPs compared with those in DEWs and HCs (P<0.05). The order of diagnostic accuracy between CWPs and DEWs depicted by the receiver operating characteristic (ROC) curve was IgG2, IgM, IgG1, IgG3, and IgA. Significantly higher IgG1/IgG3 and IgG2/IgG3 ratios were observed in the CWP group than in DEW and HC groups. Based on the IgG2/IgG3 ratio, the area under the ROC curve between CWP and DEW was 0.785 (95% CI 0.723-0.838), with a sensitivity of 73.1% and a specificity of 73.4%. Our findings suggest that IgG1, IgG2, IgM, and IgA are higher in the CWPs than DEWs and HCs. The IgG2/IgG3 ratio provides a viable alternative for the diagnosis of CWP.http://dx.doi.org/10.1155/2023/9233386 |
| spellingShingle | Zhao-Guo Li Bai-Cun Li Zhi-Wei Li Hui-Yuan Hu Xia Ma Hong Cao Zhi-Hua Yu Hua-Ping Dai Jing Wang Chen Wang The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers’ Pneumoconiosis Journal of Immunology Research |
| title | The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers’ Pneumoconiosis |
| title_full | The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers’ Pneumoconiosis |
| title_fullStr | The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers’ Pneumoconiosis |
| title_full_unstemmed | The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers’ Pneumoconiosis |
| title_short | The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers’ Pneumoconiosis |
| title_sort | potential diagnostic biomarkers for the igg subclass in coal workers pneumoconiosis |
| url | http://dx.doi.org/10.1155/2023/9233386 |
| work_keys_str_mv | AT zhaoguoli thepotentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT baicunli thepotentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT zhiweili thepotentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT huiyuanhu thepotentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT xiama thepotentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT hongcao thepotentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT zhihuayu thepotentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT huapingdai thepotentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT jingwang thepotentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT chenwang thepotentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT zhaoguoli potentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT baicunli potentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT zhiweili potentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT huiyuanhu potentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT xiama potentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT hongcao potentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT zhihuayu potentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT huapingdai potentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT jingwang potentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis AT chenwang potentialdiagnosticbiomarkersfortheiggsubclassincoalworkerspneumoconiosis |