A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells

A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells

Cell behavior is controlled through spatio-temporally localized protein activity. Despite unique and often contradictory roles played by Src-family-kinases (SFKs) in regulating cell physiology, activity patterns of individual SFKs have remained elusive. Here, we report a biosensor for specifically v...

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Bibliographic Details
Main Authors: Ananya Mukherjee, Randhir Singh, Sreeram Udayan, Sayan Biswas, Pothula Purushotham Reddy, Saumya Manmadhan, Geen George, Shilpa Kumar, Ranabir Das, Balaji M Rao, Akash Gulyani
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
biosensor
Fyn kinase
FRET
src kinases
compartmentalized
pulsatile
Online Access:https://elifesciences.org/articles/50571

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