Loss of c‐Jun N‐terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma

Loss of c‐Jun N‐terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma

Targeted inhibition of the c‐Jun N‐terminal kinases (JNKs) has shown therapeutic potential in intrahepatic cholangiocarcinoma (CCA)‐related tumorigenesis. However, the cell‐type‐specific role and mechanisms triggered by JNK in liver parenchymal cells during CCA remain largely unknown. Here, we aimed...

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Bibliographic Details
Main Authors: Francisco Javier Cubero, Mohamed Ramadan Mohamed, Marius M. Woitok, Gang Zhao, Maximilian Hatting, Yulia A. Nevzorova, Chaobo Chen, Johannes Haybaeck, Alain deBruin, Matias A. Avila, Mark V. Boekschoten, Roger J. Davis, Christian Trautwein
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2020-06-01
Series:Hepatology Communications
Online Access:https://doi.org/10.1002/hep4.1495

Internet

https://doi.org/10.1002/hep4.1495

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