A rare case of squamous cell carcinoma lung with multiple locoregional recurrences and histological transformation
A 52-year-old female nonsmoker with localized squamous cell carcinoma (T3N1M0) of lung underwent lobectomy with adjuvant chemotherapy. Two years later, the patient had her first locoregional recurrence with adenosquamous cell carcinoma, and pneumonectomy with adjuvant chemotherapy rendered her disea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Lung India |
| Subjects: | |
| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2018;volume=35;issue=6;spage=511;epage=515;aulast=Niwas |
| _version_ | 1818907722977902592 |
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| author | Ram Niwas Shibdas Chakrabarti Viswesvaran Balasubramanian Manas Kamal Sen Jagdish Chander Suri |
| author_facet | Ram Niwas Shibdas Chakrabarti Viswesvaran Balasubramanian Manas Kamal Sen Jagdish Chander Suri |
| author_sort | Ram Niwas |
| collection | DOAJ |
| description | A 52-year-old female nonsmoker with localized squamous cell carcinoma (T3N1M0) of lung underwent lobectomy with adjuvant chemotherapy. Two years later, the patient had her first locoregional recurrence with adenosquamous cell carcinoma, and pneumonectomy with adjuvant chemotherapy rendered her disease free. Subsequent isolated locoregional recurrence with squamous cell carcinoma 18 months later was treated with chemoradiotherapy and had a complete response. Patient yet again had locoregional recurrence after 4 years and had progressive disease despite subsequent multiple line of treatment with platinum-based chemotherapy, stereotactic body radiation therapy, and nivolumab. This case is unique in presentation due to prolonged survival with multiple line of treatment of recurrent locoregional tumor without distant metastasis and alteration in the histology of tumor during illness. |
| first_indexed | 2024-12-19T21:59:39Z |
| format | Article |
| id | doaj.art-828f204bc86a491c969dac0fcf2638fc |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-12-19T21:59:39Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-828f204bc86a491c969dac0fcf2638fc2022-12-21T20:04:11ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2018-01-0135651151510.4103/lungindia.lungindia_221_17A rare case of squamous cell carcinoma lung with multiple locoregional recurrences and histological transformationRam NiwasShibdas ChakrabartiViswesvaran BalasubramanianManas Kamal SenJagdish Chander SuriA 52-year-old female nonsmoker with localized squamous cell carcinoma (T3N1M0) of lung underwent lobectomy with adjuvant chemotherapy. Two years later, the patient had her first locoregional recurrence with adenosquamous cell carcinoma, and pneumonectomy with adjuvant chemotherapy rendered her disease free. Subsequent isolated locoregional recurrence with squamous cell carcinoma 18 months later was treated with chemoradiotherapy and had a complete response. Patient yet again had locoregional recurrence after 4 years and had progressive disease despite subsequent multiple line of treatment with platinum-based chemotherapy, stereotactic body radiation therapy, and nivolumab. This case is unique in presentation due to prolonged survival with multiple line of treatment of recurrent locoregional tumor without distant metastasis and alteration in the histology of tumor during illness.http://www.lungindia.com/article.asp?issn=0970-2113;year=2018;volume=35;issue=6;spage=511;epage=515;aulast=NiwasChemoradiotherapyhistological transformationlobectomylocoregional recurrencenon-small cell lung cancerpneumonectomysquamous cell carcinoma |
| spellingShingle | Ram Niwas Shibdas Chakrabarti Viswesvaran Balasubramanian Manas Kamal Sen Jagdish Chander Suri A rare case of squamous cell carcinoma lung with multiple locoregional recurrences and histological transformation Lung India Chemoradiotherapy histological transformation lobectomy locoregional recurrence non-small cell lung cancer pneumonectomy squamous cell carcinoma |
| title | A rare case of squamous cell carcinoma lung with multiple locoregional recurrences and histological transformation |
| title_full | A rare case of squamous cell carcinoma lung with multiple locoregional recurrences and histological transformation |
| title_fullStr | A rare case of squamous cell carcinoma lung with multiple locoregional recurrences and histological transformation |
| title_full_unstemmed | A rare case of squamous cell carcinoma lung with multiple locoregional recurrences and histological transformation |
| title_short | A rare case of squamous cell carcinoma lung with multiple locoregional recurrences and histological transformation |
| title_sort | rare case of squamous cell carcinoma lung with multiple locoregional recurrences and histological transformation |
| topic | Chemoradiotherapy histological transformation lobectomy locoregional recurrence non-small cell lung cancer pneumonectomy squamous cell carcinoma |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2018;volume=35;issue=6;spage=511;epage=515;aulast=Niwas |
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