Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain

Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain

Peripheral mechanisms of primary headaches such as a migraine remain unclear. Meningeal afferents surrounded by multiple mast cells have been suggested as a major source of migraine pain. Extracellular ATP released during migraine attacks is a likely candidate for activating meningeal afferents via...

Full description

Bibliographic Details
Main Authors: Ksenia Koroleva, Oleg Gafurov, Valeriia Guselnikova, Dilyara Nurkhametova, Raisa Giniatullina, Guzel Sitdikova, Olli S. Mattila, Perttu J. Lindsberg, Tarja Maarit Malm, Rashid Giniatullin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ATP
5-HT3
mast cells
pain
migraine
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00195/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00195/full

Similar Items