Collagen - Annona polysaccharide scaffolds with tetrahydrocurcumin loaded microspheres for antimicrobial wound dressing
Biomaterials have a vital role in the field of tissue engineering. In this study, we have developed a collagen hybrid scaffold comprising Annona reticulata fruit polysaccharide with a synergistic combination of Tetrahydrocurcumin (THC)-loaded ethyl cellulose (EC) microspheres with cinnamon bark extr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893922000226 |
| _version_ | 1818252780012306432 |
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| author | Chinnaiyan Senthilkumar Perumal Ramesh Kannan Pannerselvam Balashanmugam Subramanian Raghunandhakumar Perumal Sathiamurthi Singaravelu Sivakumar Arockiarajan A Soloman Agnes Mary Balaraman Madhan |
| author_facet | Chinnaiyan Senthilkumar Perumal Ramesh Kannan Pannerselvam Balashanmugam Subramanian Raghunandhakumar Perumal Sathiamurthi Singaravelu Sivakumar Arockiarajan A Soloman Agnes Mary Balaraman Madhan |
| author_sort | Chinnaiyan Senthilkumar |
| collection | DOAJ |
| description | Biomaterials have a vital role in the field of tissue engineering. In this study, we have developed a collagen hybrid scaffold comprising Annona reticulata fruit polysaccharide with a synergistic combination of Tetrahydrocurcumin (THC)-loaded ethyl cellulose (EC) microspheres with cinnamon bark extract as a cross-linking agent. Response Surface Methodology (RSM) was used to optimize the parameters for microwave-assisted extraction of polysaccharides from Annona reticulata. Further, the structural features of extracted polysaccharides were characterized by 13C CP/MAS NMR, LC-MS-MS, XRD, and TGA. The polysaccharide showed strong antioxidant activity analyzed by the DPPH method. The hybrid scaffold exhibits porous and interconnected morphology and shows better thermal stability due to strong interaction. The antimicrobial activity and sustained release of THC suggest that the hybrid scaffold could be an excellent biomaterial for antibacterial wound dressing applications. |
| first_indexed | 2024-12-12T16:29:37Z |
| format | Article |
| id | doaj.art-82900652396345679b19989dec774ca3 |
| institution | Directory Open Access Journal |
| issn | 2666-8939 |
| language | English |
| last_indexed | 2024-12-12T16:29:37Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj.art-82900652396345679b19989dec774ca32022-12-22T00:18:49ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392022-06-013100204Collagen - Annona polysaccharide scaffolds with tetrahydrocurcumin loaded microspheres for antimicrobial wound dressingChinnaiyan Senthilkumar0Perumal Ramesh Kannan1Pannerselvam Balashanmugam2Subramanian Raghunandhakumar3Perumal Sathiamurthi4Singaravelu Sivakumar5Arockiarajan A6Soloman Agnes Mary7Balaraman Madhan8Centre for Academic and Research Excellence (CARE), CSIR-Central Leather Research Institute, Chennai, Tamil Nadu, 600 020 India; Corresponding author at: Inspire faculty fellow, CSIR-CLRI, Adyar, Chennai, IndiaCentre for Biotechnology, Anna University, Chennai, Tamil Nadu, 600025 IndiaCenter for Human & Organizational Resources Development (CHORD), CSIR-Central Leather Research Institute, Chennai, Tamil Nadu, 600 020 IndiaDepartment of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, 600077 IndiaDepartment of Applied Mechanics, IIT Madras, Tamil Nadu, IndiaDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, 600036 IndiaDepartment of Applied Mechanics, IIT Madras, Tamil Nadu, IndiaCentre for Academic and Research Excellence (CARE), CSIR-Central Leather Research Institute, Chennai, Tamil Nadu, 600 020 IndiaCentre for Academic and Research Excellence (CARE), CSIR-Central Leather Research Institute, Chennai, Tamil Nadu, 600 020 India; Corresponding author at: AcSIR, CSIR-CLRI, Adyar, Chennai 600020, IndiaBiomaterials have a vital role in the field of tissue engineering. In this study, we have developed a collagen hybrid scaffold comprising Annona reticulata fruit polysaccharide with a synergistic combination of Tetrahydrocurcumin (THC)-loaded ethyl cellulose (EC) microspheres with cinnamon bark extract as a cross-linking agent. Response Surface Methodology (RSM) was used to optimize the parameters for microwave-assisted extraction of polysaccharides from Annona reticulata. Further, the structural features of extracted polysaccharides were characterized by 13C CP/MAS NMR, LC-MS-MS, XRD, and TGA. The polysaccharide showed strong antioxidant activity analyzed by the DPPH method. The hybrid scaffold exhibits porous and interconnected morphology and shows better thermal stability due to strong interaction. The antimicrobial activity and sustained release of THC suggest that the hybrid scaffold could be an excellent biomaterial for antibacterial wound dressing applications.http://www.sciencedirect.com/science/article/pii/S2666893922000226Annona reticulataPolysaccharidesAntioxidantsMicrowave-assisted extraction (MAE)Scaffold materialAntimicrobial |
| spellingShingle | Chinnaiyan Senthilkumar Perumal Ramesh Kannan Pannerselvam Balashanmugam Subramanian Raghunandhakumar Perumal Sathiamurthi Singaravelu Sivakumar Arockiarajan A Soloman Agnes Mary Balaraman Madhan Collagen - Annona polysaccharide scaffolds with tetrahydrocurcumin loaded microspheres for antimicrobial wound dressing Carbohydrate Polymer Technologies and Applications Annona reticulata Polysaccharides Antioxidants Microwave-assisted extraction (MAE) Scaffold material Antimicrobial |
| title | Collagen - Annona polysaccharide scaffolds with tetrahydrocurcumin loaded microspheres for antimicrobial wound dressing |
| title_full | Collagen - Annona polysaccharide scaffolds with tetrahydrocurcumin loaded microspheres for antimicrobial wound dressing |
| title_fullStr | Collagen - Annona polysaccharide scaffolds with tetrahydrocurcumin loaded microspheres for antimicrobial wound dressing |
| title_full_unstemmed | Collagen - Annona polysaccharide scaffolds with tetrahydrocurcumin loaded microspheres for antimicrobial wound dressing |
| title_short | Collagen - Annona polysaccharide scaffolds with tetrahydrocurcumin loaded microspheres for antimicrobial wound dressing |
| title_sort | collagen annona polysaccharide scaffolds with tetrahydrocurcumin loaded microspheres for antimicrobial wound dressing |
| topic | Annona reticulata Polysaccharides Antioxidants Microwave-assisted extraction (MAE) Scaffold material Antimicrobial |
| url | http://www.sciencedirect.com/science/article/pii/S2666893922000226 |
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