Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner

Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner

The flavivirus nonstructural protein 1 (NS1) is secreted from infected cells and contributes to endothelial barrier dysfunction and vascular leak in a tissue-dependent manner. This phenomenon occurs in part via disruption of the endothelial glycocalyx layer (EGL) lining the endothelium. Additionally...

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Bibliographic Details
Main Authors: Henry Puerta-Guardo, Scott B. Biering, Francielle Tramontini Gomes de Sousa, Jeffrey Shu, Dustin R. Glasner, Jeffrey Li, Sophie F. Blanc, P. Robert Beatty, Eva Harris
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pathogens
Subjects:
flavivirus
NS1 protein
intercellular junction complex
adherens junction
β-catenin
VE-cadherin
Online Access:https://www.mdpi.com/2076-0817/11/6/615

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