ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma
In BRAF mutant melanoma, inhibition of ERK1/2 induces FOXD3 and mediates RAF inhibitor resistance. Here, the authors show that ERK1/2 mediated phosphorylation regulates sumoylation of SOX10 which activates FOXD3, and depletion of SOX10 sensitises BRAF mutant melanoma cells to RAF inhibitors.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02354-x |
| _version_ | 1819126552266276864 |
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| author | Shujun Han Yibo Ren Wangxiao He Huadong Liu Zhe Zhi Xinliang Zhu Tielin Yang Yu Rong Bohan Ma Timothy J. Purwin Zhenlin Ouyang Caixia Li Xun Wang Xueqiang Wang Huizi Yang Yan Zheng Andrew E. Aplin Jiankang Liu Yongping Shao |
| author_facet | Shujun Han Yibo Ren Wangxiao He Huadong Liu Zhe Zhi Xinliang Zhu Tielin Yang Yu Rong Bohan Ma Timothy J. Purwin Zhenlin Ouyang Caixia Li Xun Wang Xueqiang Wang Huizi Yang Yan Zheng Andrew E. Aplin Jiankang Liu Yongping Shao |
| author_sort | Shujun Han |
| collection | DOAJ |
| description | In BRAF mutant melanoma, inhibition of ERK1/2 induces FOXD3 and mediates RAF inhibitor resistance. Here, the authors show that ERK1/2 mediated phosphorylation regulates sumoylation of SOX10 which activates FOXD3, and depletion of SOX10 sensitises BRAF mutant melanoma cells to RAF inhibitors. |
| first_indexed | 2024-12-22T07:57:51Z |
| format | Article |
| id | doaj.art-829318fdf04b499a9e045b0d41cff81a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:57:51Z |
| publishDate | 2018-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-829318fdf04b499a9e045b0d41cff81a2022-12-21T18:33:19ZengNature PortfolioNature Communications2041-17232018-01-019111410.1038/s41467-017-02354-xERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanomaShujun Han0Yibo Ren1Wangxiao He2Huadong Liu3Zhe Zhi4Xinliang Zhu5Tielin Yang6Yu Rong7Bohan Ma8Timothy J. Purwin9Zhenlin Ouyang10Caixia Li11Xun Wang12Xueqiang Wang13Huizi Yang14Yan Zheng15Andrew E. Aplin16Jiankang Liu17Yongping Shao18Frontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityDepartment of Cancer Biology, Thomas Jefferson UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityDepartment of Dermatology, the Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong UniversityDepartment of Cancer Biology, Thomas Jefferson UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityFrontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityIn BRAF mutant melanoma, inhibition of ERK1/2 induces FOXD3 and mediates RAF inhibitor resistance. Here, the authors show that ERK1/2 mediated phosphorylation regulates sumoylation of SOX10 which activates FOXD3, and depletion of SOX10 sensitises BRAF mutant melanoma cells to RAF inhibitors.https://doi.org/10.1038/s41467-017-02354-x |
| spellingShingle | Shujun Han Yibo Ren Wangxiao He Huadong Liu Zhe Zhi Xinliang Zhu Tielin Yang Yu Rong Bohan Ma Timothy J. Purwin Zhenlin Ouyang Caixia Li Xun Wang Xueqiang Wang Huizi Yang Yan Zheng Andrew E. Aplin Jiankang Liu Yongping Shao ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma Nature Communications |
| title | ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma |
| title_full | ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma |
| title_fullStr | ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma |
| title_full_unstemmed | ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma |
| title_short | ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma |
| title_sort | erk mediated phosphorylation regulates sox10 sumoylation and targets expression in mutant braf melanoma |
| url | https://doi.org/10.1038/s41467-017-02354-x |
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