NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, an...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25143-z |
| _version_ | 1818422969302515712 |
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| author | Seungyong Lee Charles Hwang Simone Marini Robert J. Tower Qizhi Qin Stefano Negri Chase A. Pagani Yuxiao Sun David M. Stepien Michael Sorkin Carrie A. Kubiak Noelle D. Visser Carolyn A. Meyers Yiyun Wang Husain A. Rasheed Jiajia Xu Sarah Miller Amanda K. Huber Liliana Minichiello Paul S. Cederna Stephen W. P. Kemp Thomas L. Clemens Aaron W. James Benjamin Levi |
| author_facet | Seungyong Lee Charles Hwang Simone Marini Robert J. Tower Qizhi Qin Stefano Negri Chase A. Pagani Yuxiao Sun David M. Stepien Michael Sorkin Carrie A. Kubiak Noelle D. Visser Carolyn A. Meyers Yiyun Wang Husain A. Rasheed Jiajia Xu Sarah Miller Amanda K. Huber Liliana Minichiello Paul S. Cederna Stephen W. P. Kemp Thomas L. Clemens Aaron W. James Benjamin Levi |
| author_sort | Seungyong Lee |
| collection | DOAJ |
| description | Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, and show that this process can be prevented by inhibition of NGF signaling. |
| first_indexed | 2024-12-14T13:34:42Z |
| format | Article |
| id | doaj.art-8294374ecf224a3ea40a708dc54a22e2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:34:42Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8294374ecf224a3ea40a708dc54a22e22022-12-21T22:59:36ZengNature PortfolioNature Communications2041-17232021-08-0112112010.1038/s41467-021-25143-zNGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue traumaSeungyong Lee0Charles Hwang1Simone Marini2Robert J. Tower3Qizhi Qin4Stefano Negri5Chase A. Pagani6Yuxiao Sun7David M. Stepien8Michael Sorkin9Carrie A. Kubiak10Noelle D. Visser11Carolyn A. Meyers12Yiyun Wang13Husain A. Rasheed14Jiajia Xu15Sarah Miller16Amanda K. Huber17Liliana Minichiello18Paul S. Cederna19Stephen W. P. Kemp20Thomas L. Clemens21Aaron W. James22Benjamin Levi23Department of Pathology, Johns Hopkins UniversityDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasDepartment of Epidemiology, University of FloridaDepartment of Orthopaedics, Johns Hopkins UniversityDepartment of Pathology, Johns Hopkins UniversityDepartment of Pathology, Johns Hopkins UniversityDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasDepartment of Pathology, Johns Hopkins UniversityDepartment of Pathology, Johns Hopkins UniversityDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasDepartment of Pathology, Johns Hopkins UniversityDepartment of Pathology, Johns Hopkins UniversityDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasDepartment of Pharmacology, Oxford UniversityDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasDepartment of Orthopaedics, Johns Hopkins UniversityDepartment of Pathology, Johns Hopkins UniversityDepartment of Surgery, Center for Organogenesis and Trauma, University of TexasSoft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, and show that this process can be prevented by inhibition of NGF signaling.https://doi.org/10.1038/s41467-021-25143-z |
| spellingShingle | Seungyong Lee Charles Hwang Simone Marini Robert J. Tower Qizhi Qin Stefano Negri Chase A. Pagani Yuxiao Sun David M. Stepien Michael Sorkin Carrie A. Kubiak Noelle D. Visser Carolyn A. Meyers Yiyun Wang Husain A. Rasheed Jiajia Xu Sarah Miller Amanda K. Huber Liliana Minichiello Paul S. Cederna Stephen W. P. Kemp Thomas L. Clemens Aaron W. James Benjamin Levi NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma Nature Communications |
| title | NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma |
| title_full | NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma |
| title_fullStr | NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma |
| title_full_unstemmed | NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma |
| title_short | NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma |
| title_sort | ngf trka signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma |
| url | https://doi.org/10.1038/s41467-021-25143-z |
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