Multi-Gene Next-Generation Sequencing Panel for Analysis of <i>BRCA1</i>/<i>BRCA2</i> and Homologous Recombination Repair Genes Alterations Metastatic Castration-Resistant Prostate Cancer

Multi-Gene Next-Generation Sequencing Panel for Analysis of <i>BRCA1</i>/<i>BRCA2</i> and Homologous Recombination Repair Genes Alterations Metastatic Castration-Resistant Prostate Cancer

Despite significant therapeutic advances, metastatic CRPC (mCRPC) remains a lethal disease. Mutations in homologous recombination repair (HRR) genes are frequent in mCRPC, and tumors harboring these mutations are known to be sensitive to PARP inhibitors. The aim of this study was to verify the techn...

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Bibliographic Details
Main Authors: Thais Maloberti, Antonio De Leo, Sara Coluccelli, Viviana Sanza, Elisa Gruppioni, Annalisa Altimari, Stefano Zagnoni, Francesca Giunchi, Francesco Vasuri, Michelangelo Fiorentino, Veronica Mollica, Simona Ferrari, Sara Miccoli, Michela Visani, Daniela Turchetti, Francesco Massari, Giovanni Tallini, Dario de Biase
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
prostatic adenocarcinoma
mCRPC
mutations
next-generation sequencing
BRCA1
BRCA2
Online Access:https://www.mdpi.com/1422-0067/24/10/8940

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