An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose Absorption
Several studies have demonstrated that high protein diets improve glucose homeostasis. Nevertheless, the mechanisms underlying this effect remain elusive. This exploratory study aims to screen and compare the acute effects of dietary proteins from different sources on intestinal glucose absorption....
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2021.769773/full |
| _version_ | 1798019630086750208 |
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| author | Camille Dugardin Léa Fleury Véronique Touche Farah Ahdach Jean Lesage Mathie Tenenbaum Nadia Everaert Nadia Everaert Olivier Briand Sophie Lestavel Rozenn Ravallec Benoit Cudennec |
| author_facet | Camille Dugardin Léa Fleury Véronique Touche Farah Ahdach Jean Lesage Mathie Tenenbaum Nadia Everaert Nadia Everaert Olivier Briand Sophie Lestavel Rozenn Ravallec Benoit Cudennec |
| author_sort | Camille Dugardin |
| collection | DOAJ |
| description | Several studies have demonstrated that high protein diets improve glucose homeostasis. Nevertheless, the mechanisms underlying this effect remain elusive. This exploratory study aims to screen and compare the acute effects of dietary proteins from different sources on intestinal glucose absorption. Six dietary proteins from various sources were thus selected and digested thanks to the INFOGEST static gastrointestinal digestion protocol. The digested proteins were able to decrease intestinal glucose absorption in vitro and ex vivo. Moreover, acute ingestion of casein and fish gelatin led to improved glucose tolerance in Wistar rats without significant effect on insulin secretion. In parallel, GLUT2 mRNA expression in enterocytes was decreased following short-term incubation with some of the digested proteins. These results strengthen the evidence that digested protein-derived peptides and amino acids are key regulators of glucose homeostasis and highlight their role in intestinal glucose absorption. |
| first_indexed | 2024-04-11T16:43:54Z |
| format | Article |
| id | doaj.art-8294ac0590454c6e8d55336193a5ec89 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T16:43:54Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-8294ac0590454c6e8d55336193a5ec892022-12-22T04:13:37ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-01-01810.3389/fnut.2021.769773769773An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose AbsorptionCamille Dugardin0Léa Fleury1Véronique Touche2Farah Ahdach3Jean Lesage4Mathie Tenenbaum5Nadia Everaert6Nadia Everaert7Olivier Briand8Sophie Lestavel9Rozenn Ravallec10Benoit Cudennec11Univ. Lille, Univ. Artois, Université de Liège, UMRT 1158 BioEcoAgro – Bénéfice santé d'hydrolysats de protéines et coproduits agro-alimentaires, Lille, FranceUniv. Lille, Univ. Artois, Université de Liège, UMRT 1158 BioEcoAgro – Bénéfice santé d'hydrolysats de protéines et coproduits agro-alimentaires, Lille, FranceUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, Lille, FranceUniv. Lille, Univ. Artois, Université de Liège, UMRT 1158 BioEcoAgro – Bénéfice santé d'hydrolysats de protéines et coproduits agro-alimentaires, Lille, FranceUniv. Lille, Inserm, CHU Lille, U1286 - INFINITE, Lille, FranceUniv. Lille, Univ. Artois, Université de Liège, UMRT 1158 BioEcoAgro – Bénéfice santé d'hydrolysats de protéines et coproduits agro-alimentaires, Lille, FranceUniv. Lille, Univ. Artois, Université de Liège, UMRT 1158 BioEcoAgro – Bénéfice santé d'hydrolysats de protéines et coproduits agro-alimentaires, Lille, FranceAnimal and Human Health Engineering, Department of Biosystems, Katholieke Universiteit Leuven, Heverlee, BelgiumUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, Lille, FranceUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, Lille, FranceUniv. Lille, Univ. Artois, Université de Liège, UMRT 1158 BioEcoAgro – Bénéfice santé d'hydrolysats de protéines et coproduits agro-alimentaires, Lille, FranceUniv. Lille, Univ. Artois, Université de Liège, UMRT 1158 BioEcoAgro – Bénéfice santé d'hydrolysats de protéines et coproduits agro-alimentaires, Lille, FranceSeveral studies have demonstrated that high protein diets improve glucose homeostasis. Nevertheless, the mechanisms underlying this effect remain elusive. This exploratory study aims to screen and compare the acute effects of dietary proteins from different sources on intestinal glucose absorption. Six dietary proteins from various sources were thus selected and digested thanks to the INFOGEST static gastrointestinal digestion protocol. The digested proteins were able to decrease intestinal glucose absorption in vitro and ex vivo. Moreover, acute ingestion of casein and fish gelatin led to improved glucose tolerance in Wistar rats without significant effect on insulin secretion. In parallel, GLUT2 mRNA expression in enterocytes was decreased following short-term incubation with some of the digested proteins. These results strengthen the evidence that digested protein-derived peptides and amino acids are key regulators of glucose homeostasis and highlight their role in intestinal glucose absorption.https://www.frontiersin.org/articles/10.3389/fnut.2021.769773/fulldigested proteinsintestinal glucose absorptionSGLT1GLUT2glucose tolerance |
| spellingShingle | Camille Dugardin Léa Fleury Véronique Touche Farah Ahdach Jean Lesage Mathie Tenenbaum Nadia Everaert Nadia Everaert Olivier Briand Sophie Lestavel Rozenn Ravallec Benoit Cudennec An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose Absorption Frontiers in Nutrition digested proteins intestinal glucose absorption SGLT1 GLUT2 glucose tolerance |
| title | An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose Absorption |
| title_full | An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose Absorption |
| title_fullStr | An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose Absorption |
| title_full_unstemmed | An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose Absorption |
| title_short | An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose Absorption |
| title_sort | exploratory study of the role of dietary proteins in the regulation of intestinal glucose absorption |
| topic | digested proteins intestinal glucose absorption SGLT1 GLUT2 glucose tolerance |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2021.769773/full |
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