An overview of mouse models of hepatocellular carcinoma
Abstract Hepatocellular carcinoma (HCC) has become a severe burden on global health due to its high morbidity and mortality rates. However, effective treatments for HCC are limited. The lack of suitable preclinical models may contribute to a major failure of drug development for HCC. Here, we overvi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Infectious Agents and Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13027-023-00524-9 |
| _version_ | 1797578027468587008 |
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| author | Hua-chuan Zheng Hang Xue Wen-Jing Yun |
| author_facet | Hua-chuan Zheng Hang Xue Wen-Jing Yun |
| author_sort | Hua-chuan Zheng |
| collection | DOAJ |
| description | Abstract Hepatocellular carcinoma (HCC) has become a severe burden on global health due to its high morbidity and mortality rates. However, effective treatments for HCC are limited. The lack of suitable preclinical models may contribute to a major failure of drug development for HCC. Here, we overview several well-established mouse models of HCC, including genetically engineered mice, chemically-induced models, implantation models, and humanized mice. Immunotherapy studies of HCC have been a hot topic. Therefore, we will introduce the application of mouse models of HCC in immunotherapy. This is followed by a discussion of some other models of HCC-related liver diseases, including non-alcoholic fatty liver disease (NAFLD), hepatitis B and C virus infection, and liver fibrosis and cirrhosis. Together these provide researchers with a current overview of the mouse models of HCC and assist in the application of appropriate models for their research. |
| first_indexed | 2024-03-10T22:16:30Z |
| format | Article |
| id | doaj.art-8294e0af71ab4bb7ba14d8807a45580e |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-03-10T22:16:30Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-8294e0af71ab4bb7ba14d8807a45580e2023-11-19T12:25:36ZengBMCInfectious Agents and Cancer1750-93782023-09-0118111710.1186/s13027-023-00524-9An overview of mouse models of hepatocellular carcinomaHua-chuan Zheng0Hang Xue1Wen-Jing Yun2Department of Oncology and Central Laboratory, The Affiliated Hospital of Chengde Medical UniversityDepartment of Oncology and Central Laboratory, The Affiliated Hospital of Chengde Medical UniversityDepartment of Oncology and Central Laboratory, The Affiliated Hospital of Chengde Medical UniversityAbstract Hepatocellular carcinoma (HCC) has become a severe burden on global health due to its high morbidity and mortality rates. However, effective treatments for HCC are limited. The lack of suitable preclinical models may contribute to a major failure of drug development for HCC. Here, we overview several well-established mouse models of HCC, including genetically engineered mice, chemically-induced models, implantation models, and humanized mice. Immunotherapy studies of HCC have been a hot topic. Therefore, we will introduce the application of mouse models of HCC in immunotherapy. This is followed by a discussion of some other models of HCC-related liver diseases, including non-alcoholic fatty liver disease (NAFLD), hepatitis B and C virus infection, and liver fibrosis and cirrhosis. Together these provide researchers with a current overview of the mouse models of HCC and assist in the application of appropriate models for their research.https://doi.org/10.1186/s13027-023-00524-9Animal modelHepatocellular carcinomaImmunotherapy |
| spellingShingle | Hua-chuan Zheng Hang Xue Wen-Jing Yun An overview of mouse models of hepatocellular carcinoma Infectious Agents and Cancer Animal model Hepatocellular carcinoma Immunotherapy |
| title | An overview of mouse models of hepatocellular carcinoma |
| title_full | An overview of mouse models of hepatocellular carcinoma |
| title_fullStr | An overview of mouse models of hepatocellular carcinoma |
| title_full_unstemmed | An overview of mouse models of hepatocellular carcinoma |
| title_short | An overview of mouse models of hepatocellular carcinoma |
| title_sort | overview of mouse models of hepatocellular carcinoma |
| topic | Animal model Hepatocellular carcinoma Immunotherapy |
| url | https://doi.org/10.1186/s13027-023-00524-9 |
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