Cognition and functioning in bipolar depression
Objectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cog...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Psiquiatria (ABP)
2016-01-01
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| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016005003101&lng=en&tlng=en |
| _version_ | 1819107873607647232 |
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| author | Natalia S. Kapczinski Joana C. Narvaez Pedro V. Magalhães Joana Bücker Ana C. Peuker Ana C. Loredo Federico Troiano Letícia Czepielewski Adriane Rosa Gabriel Fries Clarissa S. Gama |
| author_facet | Natalia S. Kapczinski Joana C. Narvaez Pedro V. Magalhães Joana Bücker Ana C. Peuker Ana C. Loredo Federico Troiano Letícia Czepielewski Adriane Rosa Gabriel Fries Clarissa S. Gama |
| author_sort | Natalia S. Kapczinski |
| collection | DOAJ |
| description | Objectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. Methods: Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and education level. Cognitive function was assessed with a neuropsychological test battery. Functioning was assessed with the Functioning Assessment Short Test. Results: In patients, severe depression was associated with poorer cognitive performance on measures of executive function. Patients with severe depression showed worse global functioning than those with moderate depression (z = 2.54, p = 0.011). In patients with severe depression, lower global functioning was associated with lower scores in working memory (r = -0.200, p = 0.010), and executive function (r = -0.210, p = 0.007; and r = 0.293, p < 0.001). Conclusion: Our findings suggest cognitive impairment and global functioning impairment are associated with the severity of depressive symptoms in bipolar depression. Intensive treatment of depressive symptoms in patients with BD is crucial to improve cognitive functioning and, consequently, functional outcomes. |
| first_indexed | 2024-12-22T03:00:57Z |
| format | Article |
| id | doaj.art-8295620c06a948fb9db22fae7f2ccbbe |
| institution | Directory Open Access Journal |
| issn | 1809-452X |
| language | English |
| last_indexed | 2024-12-22T03:00:57Z |
| publishDate | 2016-01-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-8295620c06a948fb9db22fae7f2ccbbe2022-12-21T18:41:11ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2016-01-01010.1590/1516-4446-2014-1558S1516-44462016005003101Cognition and functioning in bipolar depressionNatalia S. KapczinskiJoana C. NarvaezPedro V. MagalhãesJoana BückerAna C. PeukerAna C. LoredoFederico TroianoLetícia CzepielewskiAdriane RosaGabriel FriesClarissa S. GamaObjectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. Methods: Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and education level. Cognitive function was assessed with a neuropsychological test battery. Functioning was assessed with the Functioning Assessment Short Test. Results: In patients, severe depression was associated with poorer cognitive performance on measures of executive function. Patients with severe depression showed worse global functioning than those with moderate depression (z = 2.54, p = 0.011). In patients with severe depression, lower global functioning was associated with lower scores in working memory (r = -0.200, p = 0.010), and executive function (r = -0.210, p = 0.007; and r = 0.293, p < 0.001). Conclusion: Our findings suggest cognitive impairment and global functioning impairment are associated with the severity of depressive symptoms in bipolar depression. Intensive treatment of depressive symptoms in patients with BD is crucial to improve cognitive functioning and, consequently, functional outcomes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016005003101&lng=en&tlng=enMemorymood disorders, bipolartests/interviews, psychometriccognitive neuroscience, outcome studies |
| spellingShingle | Natalia S. Kapczinski Joana C. Narvaez Pedro V. Magalhães Joana Bücker Ana C. Peuker Ana C. Loredo Federico Troiano Letícia Czepielewski Adriane Rosa Gabriel Fries Clarissa S. Gama Cognition and functioning in bipolar depression Brazilian Journal of Psychiatry Memory mood disorders, bipolar tests/interviews, psychometric cognitive neuroscience, outcome studies |
| title | Cognition and functioning in bipolar depression |
| title_full | Cognition and functioning in bipolar depression |
| title_fullStr | Cognition and functioning in bipolar depression |
| title_full_unstemmed | Cognition and functioning in bipolar depression |
| title_short | Cognition and functioning in bipolar depression |
| title_sort | cognition and functioning in bipolar depression |
| topic | Memory mood disorders, bipolar tests/interviews, psychometric cognitive neuroscience, outcome studies |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016005003101&lng=en&tlng=en |
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