Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial
Background and AimsThe clinical efficacy of fecal microbiota transplantation (FMT) in patients with non-alcoholic fatty liver disease (NAFLD) and the variant effects of FMT on lean and obese NAFLD patients remain elusive. Our study aimed to determine the clinical efficacy and safety of FMT for patie...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.759306/full |
| _version_ | 1818117742679556096 |
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| author | Lanfeng Xue Zhiliang Deng Wenhui Luo Xingxiang He Yu Chen |
| author_facet | Lanfeng Xue Zhiliang Deng Wenhui Luo Xingxiang He Yu Chen |
| author_sort | Lanfeng Xue |
| collection | DOAJ |
| description | Background and AimsThe clinical efficacy of fecal microbiota transplantation (FMT) in patients with non-alcoholic fatty liver disease (NAFLD) and the variant effects of FMT on lean and obese NAFLD patients remain elusive. Our study aimed to determine the clinical efficacy and safety of FMT for patients with NAFLD, elucidating its different influences on lean and obese patients with NAFLD.MethodsWe performed a randomized and controlled clinical trial. Patients in the non-FMT group were administered oral probiotics. In the FMT group, patients were randomized to receive FMT with donor stool (heterologous) via colonoscopy, followed by three enemas over 3 days. Both groups were also required to maintain a healthy diet and keep regular exercise for more than 40 min every day. They returned to the hospital for reexamination 1 month after treatment.ResultsFMT can decrease the fat accumulation in the liver by improving the gut microbiota dysbiosis, thus attenuating fatty liver disease. Significant differences in the clinical features and gut microbiota between lean and obese NAFLD patients were unveiled. Moreover, FMT had better effects on gut microbiota reconstruction in lean NAFLD than in obese NAFLD patients.ConclusionsFMT could successfully improve the therapeutic effects on patients with NAFLD, and its clinical efficacy was higher in lean NAFLD than in obese NAFLD patients. |
| first_indexed | 2024-12-11T04:43:15Z |
| format | Article |
| id | doaj.art-82966da47306434d8b6dd0de1009d41a |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-11T04:43:15Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-82966da47306434d8b6dd0de1009d41a2022-12-22T01:20:33ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-07-011210.3389/fcimb.2022.759306759306Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical TrialLanfeng Xue0Zhiliang Deng1Wenhui Luo2Xingxiang He3Yu Chen4Department of Gastroenterology, The Seventh Affiliated Hospital of Southern Medical University, Foshan, ChinaDepartment of Gastroenterology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, ChinaDepartment of Gastroenterology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, ChinaDepartment of Gastroenterology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, ChinaDepartment of Gastroenterology, The Seventh Affiliated Hospital of Southern Medical University, Foshan, ChinaBackground and AimsThe clinical efficacy of fecal microbiota transplantation (FMT) in patients with non-alcoholic fatty liver disease (NAFLD) and the variant effects of FMT on lean and obese NAFLD patients remain elusive. Our study aimed to determine the clinical efficacy and safety of FMT for patients with NAFLD, elucidating its different influences on lean and obese patients with NAFLD.MethodsWe performed a randomized and controlled clinical trial. Patients in the non-FMT group were administered oral probiotics. In the FMT group, patients were randomized to receive FMT with donor stool (heterologous) via colonoscopy, followed by three enemas over 3 days. Both groups were also required to maintain a healthy diet and keep regular exercise for more than 40 min every day. They returned to the hospital for reexamination 1 month after treatment.ResultsFMT can decrease the fat accumulation in the liver by improving the gut microbiota dysbiosis, thus attenuating fatty liver disease. Significant differences in the clinical features and gut microbiota between lean and obese NAFLD patients were unveiled. Moreover, FMT had better effects on gut microbiota reconstruction in lean NAFLD than in obese NAFLD patients.ConclusionsFMT could successfully improve the therapeutic effects on patients with NAFLD, and its clinical efficacy was higher in lean NAFLD than in obese NAFLD patients.https://www.frontiersin.org/articles/10.3389/fcimb.2022.759306/fullfecal microbiota transplantationnon-alcoholic fatty liver diseasegut microbiotalean NAFLDobese NAFLD |
| spellingShingle | Lanfeng Xue Zhiliang Deng Wenhui Luo Xingxiang He Yu Chen Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial Frontiers in Cellular and Infection Microbiology fecal microbiota transplantation non-alcoholic fatty liver disease gut microbiota lean NAFLD obese NAFLD |
| title | Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial |
| title_full | Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial |
| title_fullStr | Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial |
| title_full_unstemmed | Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial |
| title_short | Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial |
| title_sort | effect of fecal microbiota transplantation on non alcoholic fatty liver disease a randomized clinical trial |
| topic | fecal microbiota transplantation non-alcoholic fatty liver disease gut microbiota lean NAFLD obese NAFLD |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.759306/full |
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