Persistent Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia: Host, Pathogen, and Treatment
Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a devastating pathogen responsible for a variety of life-threatening infections. A distinctive characteristic of this pathogen is its ability to persist in the bloodstream for several days despite seemingly appropriate antibiot...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/3/455 |
| _version_ | 1797613859492593664 |
|---|---|
| author | Joshua B. Parsons Annette C. Westgeest Brian P. Conlon Vance G. Fowler |
| author_facet | Joshua B. Parsons Annette C. Westgeest Brian P. Conlon Vance G. Fowler |
| author_sort | Joshua B. Parsons |
| collection | DOAJ |
| description | Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a devastating pathogen responsible for a variety of life-threatening infections. A distinctive characteristic of this pathogen is its ability to persist in the bloodstream for several days despite seemingly appropriate antibiotics. Persistent MRSA bacteremia is common and is associated with poor clinical outcomes. The etiology of persistent MRSA bacteremia is a result of the complex interplay between the host, the pathogen, and the antibiotic used to treat the infection. In this review, we explore the factors related to each component of the host–pathogen interaction and discuss the clinical relevance of each element. Next, we discuss the treatment options and diagnostic approaches for the management of persistent MRSA bacteremia. |
| first_indexed | 2024-03-11T07:01:37Z |
| format | Article |
| id | doaj.art-829678a3897842c29e9fd2a1727b7d73 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T07:01:37Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-829678a3897842c29e9fd2a1727b7d732023-11-17T09:13:11ZengMDPI AGAntibiotics2079-63822023-02-0112345510.3390/antibiotics12030455Persistent Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia: Host, Pathogen, and TreatmentJoshua B. Parsons0Annette C. Westgeest1Brian P. Conlon2Vance G. Fowler3Department of Medicine, Division of Infectious Disease, Duke University Medical Center, Durham, NC 27710, USADepartment of Medicine, Division of Infectious Disease, Duke University Medical Center, Durham, NC 27710, USADepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Medicine, Division of Infectious Disease, Duke University Medical Center, Durham, NC 27710, USAMethicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a devastating pathogen responsible for a variety of life-threatening infections. A distinctive characteristic of this pathogen is its ability to persist in the bloodstream for several days despite seemingly appropriate antibiotics. Persistent MRSA bacteremia is common and is associated with poor clinical outcomes. The etiology of persistent MRSA bacteremia is a result of the complex interplay between the host, the pathogen, and the antibiotic used to treat the infection. In this review, we explore the factors related to each component of the host–pathogen interaction and discuss the clinical relevance of each element. Next, we discuss the treatment options and diagnostic approaches for the management of persistent MRSA bacteremia.https://www.mdpi.com/2079-6382/12/3/455<i>Staphylococcus aureus</i>persistent bacteremiaMRSA |
| spellingShingle | Joshua B. Parsons Annette C. Westgeest Brian P. Conlon Vance G. Fowler Persistent Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia: Host, Pathogen, and Treatment Antibiotics <i>Staphylococcus aureus</i> persistent bacteremia MRSA |
| title | Persistent Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia: Host, Pathogen, and Treatment |
| title_full | Persistent Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia: Host, Pathogen, and Treatment |
| title_fullStr | Persistent Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia: Host, Pathogen, and Treatment |
| title_full_unstemmed | Persistent Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia: Host, Pathogen, and Treatment |
| title_short | Persistent Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia: Host, Pathogen, and Treatment |
| title_sort | persistent methicillin resistant i staphylococcus aureus i bacteremia host pathogen and treatment |
| topic | <i>Staphylococcus aureus</i> persistent bacteremia MRSA |
| url | https://www.mdpi.com/2079-6382/12/3/455 |
| work_keys_str_mv | AT joshuabparsons persistentmethicillinresistantistaphylococcusaureusibacteremiahostpathogenandtreatment AT annettecwestgeest persistentmethicillinresistantistaphylococcusaureusibacteremiahostpathogenandtreatment AT brianpconlon persistentmethicillinresistantistaphylococcusaureusibacteremiahostpathogenandtreatment AT vancegfowler persistentmethicillinresistantistaphylococcusaureusibacteremiahostpathogenandtreatment |