Effects of Low Molecular Weight Peptides from Red Shrimp (<i>Solenocera crassicornis</i>) Head on Immune Response in Immunosuppressed Mice
This study aimed to investigate the immunoenhancement effects of low molecular weight peptides (SCHPs-F1) from red shrimp (<i>Solenocera crassicornis</i>) head against cyclophosphamide (CTX)-induced immunosuppressed mice. ICR mice were intraperitoneally injected with 80 mg/kg CTX for 5 c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10297 |
| _version_ | 1797594283864227840 |
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| author | Rui Zhao Shuoqi Jiang Yunping Tang Guofang Ding |
| author_facet | Rui Zhao Shuoqi Jiang Yunping Tang Guofang Ding |
| author_sort | Rui Zhao |
| collection | DOAJ |
| description | This study aimed to investigate the immunoenhancement effects of low molecular weight peptides (SCHPs-F1) from red shrimp (<i>Solenocera crassicornis</i>) head against cyclophosphamide (CTX)-induced immunosuppressed mice. ICR mice were intraperitoneally injected with 80 mg/kg CTX for 5 consecutive days to establish the immunosuppressive model and then intragastrically administered with SCHPs-F1 (100 mg/kg, 200 mg/kg, and 400 mg/kg) to investigate its improving effect on immunosuppressed mice and explore its potential mechanism using Western blot. SCHPs-F1 could effectively improve the spleen and thymus index, promoting serum cytokines and immunoglobulins production and upregulating the proliferative activity of splenic lymphocytes and peritoneal macrophages of the CTX-treated mice. Moreover, SCHPs-F1 could significantly promote the expression levels of related proteins in the NF-κB and MAPK pathways in the spleen tissues. Overall, the results suggested that SCHPs-F1 could effectively ameliorate the immune deficiency caused by CTX and had the potential to explore as an immunomodulator in functional foods or dietary supplements. |
| first_indexed | 2024-03-11T02:20:28Z |
| format | Article |
| id | doaj.art-8297da8222644fbbb486f5766b32e058 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:20:28Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8297da8222644fbbb486f5766b32e0582023-11-18T10:51:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121029710.3390/ijms241210297Effects of Low Molecular Weight Peptides from Red Shrimp (<i>Solenocera crassicornis</i>) Head on Immune Response in Immunosuppressed MiceRui Zhao0Shuoqi Jiang1Yunping Tang2Guofang Ding3Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, ChinaZhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, ChinaZhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, ChinaZhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, ChinaThis study aimed to investigate the immunoenhancement effects of low molecular weight peptides (SCHPs-F1) from red shrimp (<i>Solenocera crassicornis</i>) head against cyclophosphamide (CTX)-induced immunosuppressed mice. ICR mice were intraperitoneally injected with 80 mg/kg CTX for 5 consecutive days to establish the immunosuppressive model and then intragastrically administered with SCHPs-F1 (100 mg/kg, 200 mg/kg, and 400 mg/kg) to investigate its improving effect on immunosuppressed mice and explore its potential mechanism using Western blot. SCHPs-F1 could effectively improve the spleen and thymus index, promoting serum cytokines and immunoglobulins production and upregulating the proliferative activity of splenic lymphocytes and peritoneal macrophages of the CTX-treated mice. Moreover, SCHPs-F1 could significantly promote the expression levels of related proteins in the NF-κB and MAPK pathways in the spleen tissues. Overall, the results suggested that SCHPs-F1 could effectively ameliorate the immune deficiency caused by CTX and had the potential to explore as an immunomodulator in functional foods or dietary supplements.https://www.mdpi.com/1422-0067/24/12/10297low molecular weight peptidesimmunoenhancementcyclophosphamide<i>Solenocera crassicornis</i>signal pathways |
| spellingShingle | Rui Zhao Shuoqi Jiang Yunping Tang Guofang Ding Effects of Low Molecular Weight Peptides from Red Shrimp (<i>Solenocera crassicornis</i>) Head on Immune Response in Immunosuppressed Mice International Journal of Molecular Sciences low molecular weight peptides immunoenhancement cyclophosphamide <i>Solenocera crassicornis</i> signal pathways |
| title | Effects of Low Molecular Weight Peptides from Red Shrimp (<i>Solenocera crassicornis</i>) Head on Immune Response in Immunosuppressed Mice |
| title_full | Effects of Low Molecular Weight Peptides from Red Shrimp (<i>Solenocera crassicornis</i>) Head on Immune Response in Immunosuppressed Mice |
| title_fullStr | Effects of Low Molecular Weight Peptides from Red Shrimp (<i>Solenocera crassicornis</i>) Head on Immune Response in Immunosuppressed Mice |
| title_full_unstemmed | Effects of Low Molecular Weight Peptides from Red Shrimp (<i>Solenocera crassicornis</i>) Head on Immune Response in Immunosuppressed Mice |
| title_short | Effects of Low Molecular Weight Peptides from Red Shrimp (<i>Solenocera crassicornis</i>) Head on Immune Response in Immunosuppressed Mice |
| title_sort | effects of low molecular weight peptides from red shrimp i solenocera crassicornis i head on immune response in immunosuppressed mice |
| topic | low molecular weight peptides immunoenhancement cyclophosphamide <i>Solenocera crassicornis</i> signal pathways |
| url | https://www.mdpi.com/1422-0067/24/12/10297 |
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