Scavenger receptor B2 as a receptor for hand, foot and Mouth disease and severe neurological diseases
Enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease (HFMD). Infection with EV71 is occasionally associated with severe neurological diseases such as acute encephalitis, acute flaccid paralysis and cardiopulmonary failure. Because cellular receptors for viruses...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-02-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00032/full |
| _version_ | 1818949510327435264 |
|---|---|
| author | Seiya eYamayoshi Ken eFujii Satoshi eKoike |
| author_facet | Seiya eYamayoshi Ken eFujii Satoshi eKoike |
| author_sort | Seiya eYamayoshi |
| collection | DOAJ |
| description | Enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease (HFMD). Infection with EV71 is occasionally associated with severe neurological diseases such as acute encephalitis, acute flaccid paralysis and cardiopulmonary failure. Because cellular receptors for viruses play an important role in cell, tissue and species tropism, it is important to identify and characterize the receptor molecule. Recently, cellular receptors and host factors that stimulate EV71 infection have been identified. Several lines of evidence suggest that scavenger receptor class B, member 2 (SCARB2) plays critical roles in efficient EV71 infection and the development of disease in humans. In this review, we will summarize the findings of recent studies on EV71 infection and on the roles of SCARB2. |
| first_indexed | 2024-12-20T09:03:50Z |
| format | Article |
| id | doaj.art-8298504efb494e8caccb9c9c2f52d07b |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-20T09:03:50Z |
| publishDate | 2012-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-8298504efb494e8caccb9c9c2f52d07b2022-12-21T19:45:48ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2012-02-01310.3389/fmicb.2012.0003221447Scavenger receptor B2 as a receptor for hand, foot and Mouth disease and severe neurological diseasesSeiya eYamayoshi0Ken eFujii1Satoshi eKoike2Tokyo Metropolitan Institute of Medical ScienceTokyo Metropolitan Institute of Medical ScienceTokyo Metropolitan Institute of Medical ScienceEnterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease (HFMD). Infection with EV71 is occasionally associated with severe neurological diseases such as acute encephalitis, acute flaccid paralysis and cardiopulmonary failure. Because cellular receptors for viruses play an important role in cell, tissue and species tropism, it is important to identify and characterize the receptor molecule. Recently, cellular receptors and host factors that stimulate EV71 infection have been identified. Several lines of evidence suggest that scavenger receptor class B, member 2 (SCARB2) plays critical roles in efficient EV71 infection and the development of disease in humans. In this review, we will summarize the findings of recent studies on EV71 infection and on the roles of SCARB2.http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00032/fullNeurological DiseaseEV71HFMDSCARB2 |
| spellingShingle | Seiya eYamayoshi Ken eFujii Satoshi eKoike Scavenger receptor B2 as a receptor for hand, foot and Mouth disease and severe neurological diseases Frontiers in Microbiology Neurological Disease EV71 HFMD SCARB2 |
| title | Scavenger receptor B2 as a receptor for hand, foot and Mouth disease and severe neurological diseases |
| title_full | Scavenger receptor B2 as a receptor for hand, foot and Mouth disease and severe neurological diseases |
| title_fullStr | Scavenger receptor B2 as a receptor for hand, foot and Mouth disease and severe neurological diseases |
| title_full_unstemmed | Scavenger receptor B2 as a receptor for hand, foot and Mouth disease and severe neurological diseases |
| title_short | Scavenger receptor B2 as a receptor for hand, foot and Mouth disease and severe neurological diseases |
| title_sort | scavenger receptor b2 as a receptor for hand foot and mouth disease and severe neurological diseases |
| topic | Neurological Disease EV71 HFMD SCARB2 |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00032/full |
| work_keys_str_mv | AT seiyaeyamayoshi scavengerreceptorb2asareceptorforhandfootandmouthdiseaseandsevereneurologicaldiseases AT kenefujii scavengerreceptorb2asareceptorforhandfootandmouthdiseaseandsevereneurologicaldiseases AT satoshiekoike scavengerreceptorb2asareceptorforhandfootandmouthdiseaseandsevereneurologicaldiseases |