Burden of respiratory syncytial virus diseases among under 5 children in Sub-Saharan Africa: A systematic review and meta-analysis
Background: Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory infections (ALRIs) in young children. To design preventive efforts in sub-Saharan Africa, a better knowledge of the true role of RSV in pediatric ALRIs is required. Therefore we conducted a systematic r...
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Elsevier
2023-12-01
|
| Schriftenreihe: | Heliyon |
| Schlagworte: | |
| Online Zugang: | http://www.sciencedirect.com/science/article/pii/S2405844023094197 |
| _version_ | 1827577543183564800 |
|---|---|
| author | Fiseha Wadilo Wada Minyahil Tadesse Boltena Rawliegh Howe Fithamlak Bistegen Solomon Adey Feleke Tamrayehu Seyoum Andargachew Mulu Adane Mihret |
| author_facet | Fiseha Wadilo Wada Minyahil Tadesse Boltena Rawliegh Howe Fithamlak Bistegen Solomon Adey Feleke Tamrayehu Seyoum Andargachew Mulu Adane Mihret |
| author_sort | Fiseha Wadilo Wada |
| collection | DOAJ |
| description | Background: Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory infections (ALRIs) in young children. To design preventive efforts in sub-Saharan Africa, a better knowledge of the true role of RSV in pediatric ALRIs is required. Therefore we conducted a systematic review and meta-analysis of case–control studies to estimate the etiological role of RSV to ALRIs in under 5 years children in sub-Saharan Africa. Methods: This study was done according to PRISMA guidelines. PubMed, EMBASE, SCOPUS, Web of Sciences databases, and Google Scholar were used to retrieve articles. STATA software version 17 was used for data analysis. The results of all the included studies were standardized to odds ratios (ORs) with accompanying 95 % confidence intervals (95 % CIs) and the pooled estimates of ORs, attributable fraction among the exposed (AFE), and population attributable fraction (PAF) were reported. The heterogeneity was assessed using Cochrane chi-square (I 2) statistics. Result: A total of 6200 cases and 4986 controls from 14 articles that fulfilled the inclusion criteria were included. The pooled prevalence of RSV among cases and controls was 23.52 % [95 % CI (20.68–26.47)] and 4.33 % [95 % CI (3.11–5.73)], respectively. The pooled OR is 7.04 [95 % CI (4.41–11.24)], which indicated a significant association between RSV and ALRI. Among ALRIs cases positive for RSV, the proportion of disease that was not attributable to the background rate (AFE) was 85.8 % [95 % CI (77.3–91.1)]. The fraction of ALRIs children that can be attributed to RSV (PAF) was 20.2 % [95 % CI (16–24.1)]. Conclusion: This study showed clear associations between RSV and ALRI hospitalization in young children in sub-Saharan Africa indicating the need for prophylactic measures against RSV in this age group. |
| first_indexed | 2024-03-08T21:29:16Z |
| format | Article |
| id | doaj.art-829eaf445f1144c1a33ac19a73693676 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T21:29:16Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-829eaf445f1144c1a33ac19a736936762023-12-21T07:33:17ZengElsevierHeliyon2405-84402023-12-01912e22211Burden of respiratory syncytial virus diseases among under 5 children in Sub-Saharan Africa: A systematic review and meta-analysisFiseha Wadilo Wada0Minyahil Tadesse Boltena1Rawliegh Howe2Fithamlak Bistegen Solomon3Adey Feleke4Tamrayehu Seyoum5Andargachew Mulu6Adane Mihret7Armauer Hansen Research Institute, Ministry of Health, Ethiopia; Department of Biomedical Sciences, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia; Department of Medical Laboratory Sciences, College of Health Sciences and Medicine, Wolaita Sodo University, Ethiopia; Corresponding author. Armauer Hansen Research Institute, Ministry of Health, Ethiopia.Armauer Hansen Research Institute, Ministry of Health, Ethiopia; Evidence Based Health Care, Ethiopian-Evidence Based Health Care Centre: A JBI Center of Excellence, Public Health Faculty, Institute of Health, Jimma University, Jimma, EthiopiaArmauer Hansen Research Institute, Ministry of Health, EthiopiaDepartment of Medical Laboratory Sciences, College of Health Sciences and Medicine, Wolaita Sodo University, EthiopiaDepartment of Biomedical Sciences, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, EthiopiaArmauer Hansen Research Institute, Ministry of Health, EthiopiaArmauer Hansen Research Institute, Ministry of Health, EthiopiaArmauer Hansen Research Institute, Ministry of Health, Ethiopia; Department of Microbiology, Immunology, And Parasitology, School of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaBackground: Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory infections (ALRIs) in young children. To design preventive efforts in sub-Saharan Africa, a better knowledge of the true role of RSV in pediatric ALRIs is required. Therefore we conducted a systematic review and meta-analysis of case–control studies to estimate the etiological role of RSV to ALRIs in under 5 years children in sub-Saharan Africa. Methods: This study was done according to PRISMA guidelines. PubMed, EMBASE, SCOPUS, Web of Sciences databases, and Google Scholar were used to retrieve articles. STATA software version 17 was used for data analysis. The results of all the included studies were standardized to odds ratios (ORs) with accompanying 95 % confidence intervals (95 % CIs) and the pooled estimates of ORs, attributable fraction among the exposed (AFE), and population attributable fraction (PAF) were reported. The heterogeneity was assessed using Cochrane chi-square (I 2) statistics. Result: A total of 6200 cases and 4986 controls from 14 articles that fulfilled the inclusion criteria were included. The pooled prevalence of RSV among cases and controls was 23.52 % [95 % CI (20.68–26.47)] and 4.33 % [95 % CI (3.11–5.73)], respectively. The pooled OR is 7.04 [95 % CI (4.41–11.24)], which indicated a significant association between RSV and ALRI. Among ALRIs cases positive for RSV, the proportion of disease that was not attributable to the background rate (AFE) was 85.8 % [95 % CI (77.3–91.1)]. The fraction of ALRIs children that can be attributed to RSV (PAF) was 20.2 % [95 % CI (16–24.1)]. Conclusion: This study showed clear associations between RSV and ALRI hospitalization in young children in sub-Saharan Africa indicating the need for prophylactic measures against RSV in this age group.http://www.sciencedirect.com/science/article/pii/S2405844023094197Respiratory syncytial virusALRIsChildrenNaso/oropharyngealSub-Saharan Africa |
| spellingShingle | Fiseha Wadilo Wada Minyahil Tadesse Boltena Rawliegh Howe Fithamlak Bistegen Solomon Adey Feleke Tamrayehu Seyoum Andargachew Mulu Adane Mihret Burden of respiratory syncytial virus diseases among under 5 children in Sub-Saharan Africa: A systematic review and meta-analysis Heliyon Respiratory syncytial virus ALRIs Children Naso/oropharyngeal Sub-Saharan Africa |
| title | Burden of respiratory syncytial virus diseases among under 5 children in Sub-Saharan Africa: A systematic review and meta-analysis |
| title_full | Burden of respiratory syncytial virus diseases among under 5 children in Sub-Saharan Africa: A systematic review and meta-analysis |
| title_fullStr | Burden of respiratory syncytial virus diseases among under 5 children in Sub-Saharan Africa: A systematic review and meta-analysis |
| title_full_unstemmed | Burden of respiratory syncytial virus diseases among under 5 children in Sub-Saharan Africa: A systematic review and meta-analysis |
| title_short | Burden of respiratory syncytial virus diseases among under 5 children in Sub-Saharan Africa: A systematic review and meta-analysis |
| title_sort | burden of respiratory syncytial virus diseases among under 5 children in sub saharan africa a systematic review and meta analysis |
| topic | Respiratory syncytial virus ALRIs Children Naso/oropharyngeal Sub-Saharan Africa |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023094197 |
| work_keys_str_mv | AT fisehawadilowada burdenofrespiratorysyncytialvirusdiseasesamongunder5childreninsubsaharanafricaasystematicreviewandmetaanalysis AT minyahiltadesseboltena burdenofrespiratorysyncytialvirusdiseasesamongunder5childreninsubsaharanafricaasystematicreviewandmetaanalysis AT rawlieghhowe burdenofrespiratorysyncytialvirusdiseasesamongunder5childreninsubsaharanafricaasystematicreviewandmetaanalysis AT fithamlakbistegensolomon burdenofrespiratorysyncytialvirusdiseasesamongunder5childreninsubsaharanafricaasystematicreviewandmetaanalysis AT adeyfeleke burdenofrespiratorysyncytialvirusdiseasesamongunder5childreninsubsaharanafricaasystematicreviewandmetaanalysis AT tamrayehuseyoum burdenofrespiratorysyncytialvirusdiseasesamongunder5childreninsubsaharanafricaasystematicreviewandmetaanalysis AT andargachewmulu burdenofrespiratorysyncytialvirusdiseasesamongunder5childreninsubsaharanafricaasystematicreviewandmetaanalysis AT adanemihret burdenofrespiratorysyncytialvirusdiseasesamongunder5childreninsubsaharanafricaasystematicreviewandmetaanalysis |