High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix
Microbubbles with a negligible shell are of utmost importance in the study of harmonic ultrasound contrast agents. The purpose of this study was to collect and quantify experimental pulsation footage of gas microbubbles released from tablet matrix under sonication. Radii were measured as a function...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2023-1007 |
| _version_ | 1827780171716886528 |
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| author | Anderton Nicole Carlson Craig S. Xinyue Hu Otake Naoyuki Sorjonen Joona Kudo Nobuki Ketolainen Jarkko Postema Michiel |
| author_facet | Anderton Nicole Carlson Craig S. Xinyue Hu Otake Naoyuki Sorjonen Joona Kudo Nobuki Ketolainen Jarkko Postema Michiel |
| author_sort | Anderton Nicole |
| collection | DOAJ |
| description | Microbubbles with a negligible shell are of utmost importance in the study of harmonic ultrasound contrast agents. The purpose of this study was to collect and quantify experimental pulsation footage of gas microbubbles released from tablet matrix under sonication. Radii were measured as a function of time of 50 microbubbles that had been released from tablet matrix and were subjected to 3-cycle pulses of 1-MHz ultrasound with a 0.3-MPa peak-negative pressure. The size distribution was measured, as well as pre- and postsonication radii. The experimental footage showed proof of asymmetric buckling, but also of excursion-only behaviour. The former phenomenon has been attributed to a surplus of material accumulated on the microbubble-liquid interfaces, whilst the latter phenomenon has been associated with the presence of incompressible material inside the microbubbles. The postsonication resting radii of 41 microbubbles had become less compared to the corresponding pre-sonication radii. The opposite effect was observed with eight microbubbles in the same size range. This feasibility study confirmed that the gas microbubbles released from tablet matrix may pulsate asymmetrically. Thus, they might be suitable tracers for harmonic imaging. |
| first_indexed | 2024-03-11T15:00:53Z |
| format | Article |
| id | doaj.art-829ee114ae7c4f81a584d9850eb6bdd2 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-03-11T15:00:53Z |
| publishDate | 2023-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-829ee114ae7c4f81a584d9850eb6bdd22023-10-30T07:58:11ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042023-09-0191252810.1515/cdbme-2023-1007High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrixAnderton Nicole0Carlson Craig S.1Xinyue Hu2Otake Naoyuki3Sorjonen Joona4Kudo Nobuki5Ketolainen Jarkko6Postema Michiel7BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandBioMediTech, Faculty of Medicine and Health Technology, Tampere University, Korkeakoulunkatu 3, 33720Tampere, FinlandFaculty of Information Science and Technology, Hokkaido University, Sapporo, Hokkaido, JapanFaculty of Information Science and Technology, Hokkaido University, Sapporo, Hokkaido, JapanPromisLab, School of Pharmacy, University of Eastern Finland, Kuopio, FinlandFaculty of Information Science and Technology, Hokkaido University, Sapporo, Hokkaido, JapanPromisLab, School of Pharmacy, University of Eastern Finland, Kuopio, FinlandBioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandMicrobubbles with a negligible shell are of utmost importance in the study of harmonic ultrasound contrast agents. The purpose of this study was to collect and quantify experimental pulsation footage of gas microbubbles released from tablet matrix under sonication. Radii were measured as a function of time of 50 microbubbles that had been released from tablet matrix and were subjected to 3-cycle pulses of 1-MHz ultrasound with a 0.3-MPa peak-negative pressure. The size distribution was measured, as well as pre- and postsonication radii. The experimental footage showed proof of asymmetric buckling, but also of excursion-only behaviour. The former phenomenon has been attributed to a surplus of material accumulated on the microbubble-liquid interfaces, whilst the latter phenomenon has been associated with the presence of incompressible material inside the microbubbles. The postsonication resting radii of 41 microbubbles had become less compared to the corresponding pre-sonication radii. The opposite effect was observed with eight microbubbles in the same size range. This feasibility study confirmed that the gas microbubbles released from tablet matrix may pulsate asymmetrically. Thus, they might be suitable tracers for harmonic imaging.https://doi.org/10.1515/cdbme-2023-1007micro-crystalline cellulosemcc tablet matrixcontrolled gas releaserayleigh-plesset equationbuckling |
| spellingShingle | Anderton Nicole Carlson Craig S. Xinyue Hu Otake Naoyuki Sorjonen Joona Kudo Nobuki Ketolainen Jarkko Postema Michiel High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix Current Directions in Biomedical Engineering micro-crystalline cellulose mcc tablet matrix controlled gas release rayleigh-plesset equation buckling |
| title | High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix |
| title_full | High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix |
| title_fullStr | High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix |
| title_full_unstemmed | High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix |
| title_short | High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix |
| title_sort | high speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix |
| topic | micro-crystalline cellulose mcc tablet matrix controlled gas release rayleigh-plesset equation buckling |
| url | https://doi.org/10.1515/cdbme-2023-1007 |
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