Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients
Hany Mahmoud,1 Ahmed Hamody,2 Hesham M Hefny,3 Dalia Tohamy,4 Islam Awny5 1Department of Ophthalmology, Faculty of Medicine, Sohag University, Sohag, Egypt; 2Anesthesia Department, Sohag University, Sohag, Egypt; 3Clinical Pathology Department, Sohag University, Sohag, Egypt; 4Ophthalmology Departme...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-05-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/evaluation-of-anti-sars-cov-2-iga-in-the-conjunctival-secretions-of-co-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1818991861237284864 |
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| author | Mahmoud H Hamody A M Hefny H Tohamy D Awny I |
| author_facet | Mahmoud H Hamody A M Hefny H Tohamy D Awny I |
| author_sort | Mahmoud H |
| collection | DOAJ |
| description | Hany Mahmoud,1 Ahmed Hamody,2 Hesham M Hefny,3 Dalia Tohamy,4 Islam Awny5 1Department of Ophthalmology, Faculty of Medicine, Sohag University, Sohag, Egypt; 2Anesthesia Department, Sohag University, Sohag, Egypt; 3Clinical Pathology Department, Sohag University, Sohag, Egypt; 4Ophthalmology Department, Assiut University, Assiut, Egypt; 5Department of Ophthalmology, Sohag University, Sohag, EgyptCorrespondence: Hany MahmoudDepartment of Ophthalmology, Faculty of Medicine, Sohag University, EgyptTel +20 1024368111Email drhanymahmoud@gmail.comPurpose: To assess the presence of anti-SARS-CoV-2 IgA in the conjunctival secretions of confirmed COVID-19 patients by nasopharyngeal swabs and correlate its presence with the severity of the disease, patient’s age, sex and ocular symptoms.Methods: This study included 44 positive COVID-19 patients confirmed with nasopharyngeal swabs during the period 17– 28 February 2021 at Sohag Tropical Medicine Hospital. Tears and conjunctival secretions were examined for the presence of anti-SARS-CoV-2 IgA.Results: While non-reactive results are strongly correlated to low titre and vice versa, severity showed significant correlation with neither IgA reactivity nor titre. Meanwhile, IgA reactivity did not show significant correlation with either age or sex. The reactivity and IgA titre are correlated with ocular symptoms.Conclusion: The anti-SARS-CoV-2 IgA could be found in ocular secretions in SARS-CoV-2 patients. There is no correlation with age or sex or severity of the disease; however, they are correlated with ocular symptoms.Keywords: anti-SARS-CoV-2 IgA, ocular, secretions, swab |
| first_indexed | 2024-12-20T20:16:59Z |
| format | Article |
| id | doaj.art-82a0cf5c901c4f118e81885a996f6222 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-20T20:16:59Z |
| publishDate | 2021-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-82a0cf5c901c4f118e81885a996f62222022-12-21T19:27:41ZengDove Medical PressClinical Ophthalmology1177-54832021-05-01Volume 151933193764626Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 PatientsMahmoud HHamody AM Hefny HTohamy DAwny IHany Mahmoud,1 Ahmed Hamody,2 Hesham M Hefny,3 Dalia Tohamy,4 Islam Awny5 1Department of Ophthalmology, Faculty of Medicine, Sohag University, Sohag, Egypt; 2Anesthesia Department, Sohag University, Sohag, Egypt; 3Clinical Pathology Department, Sohag University, Sohag, Egypt; 4Ophthalmology Department, Assiut University, Assiut, Egypt; 5Department of Ophthalmology, Sohag University, Sohag, EgyptCorrespondence: Hany MahmoudDepartment of Ophthalmology, Faculty of Medicine, Sohag University, EgyptTel +20 1024368111Email drhanymahmoud@gmail.comPurpose: To assess the presence of anti-SARS-CoV-2 IgA in the conjunctival secretions of confirmed COVID-19 patients by nasopharyngeal swabs and correlate its presence with the severity of the disease, patient’s age, sex and ocular symptoms.Methods: This study included 44 positive COVID-19 patients confirmed with nasopharyngeal swabs during the period 17– 28 February 2021 at Sohag Tropical Medicine Hospital. Tears and conjunctival secretions were examined for the presence of anti-SARS-CoV-2 IgA.Results: While non-reactive results are strongly correlated to low titre and vice versa, severity showed significant correlation with neither IgA reactivity nor titre. Meanwhile, IgA reactivity did not show significant correlation with either age or sex. The reactivity and IgA titre are correlated with ocular symptoms.Conclusion: The anti-SARS-CoV-2 IgA could be found in ocular secretions in SARS-CoV-2 patients. There is no correlation with age or sex or severity of the disease; however, they are correlated with ocular symptoms.Keywords: anti-SARS-CoV-2 IgA, ocular, secretions, swabhttps://www.dovepress.com/evaluation-of-anti-sars-cov-2-iga-in-the-conjunctival-secretions-of-co-peer-reviewed-fulltext-article-OPTHanti-sars-cov-2 igaocularsecretionsswab. |
| spellingShingle | Mahmoud H Hamody A M Hefny H Tohamy D Awny I Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients Clinical Ophthalmology anti-sars-cov-2 iga ocular secretions swab. |
| title | Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients |
| title_full | Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients |
| title_fullStr | Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients |
| title_full_unstemmed | Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients |
| title_short | Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients |
| title_sort | evaluation of anti sars cov 2 iga in the conjunctival secretions of covid 19 patients |
| topic | anti-sars-cov-2 iga ocular secretions swab. |
| url | https://www.dovepress.com/evaluation-of-anti-sars-cov-2-iga-in-the-conjunctival-secretions-of-co-peer-reviewed-fulltext-article-OPTH |
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