The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases
Metabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia, and hypertension, which increase the risk of CVDs’ initiation and development. Although there are many availabile drugs fo...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/29/4/758 |
| _version_ | 1797297418049421312 |
|---|---|
| author | Quanye Luo Yu Wei Xuzhen Lv Wen Chen Dongmei Yang Qinhui Tuo |
| author_facet | Quanye Luo Yu Wei Xuzhen Lv Wen Chen Dongmei Yang Qinhui Tuo |
| author_sort | Quanye Luo |
| collection | DOAJ |
| description | Metabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia, and hypertension, which increase the risk of CVDs’ initiation and development. Although there are many availabile drugs for treating MetS and related CVDs, some side effects also occur. Considering the low-level side effects, many natural products have been tried to treat MetS and CVDs. A five-cyclic triterpenoid natural product, oleanolic acid (OA), has been reported to have many pharmacologic actions such as anti-hypertension, anti-hyperlipidemia, and liver protection. OA has specific advantages in the treatment of MetS and CVDs. OA achieves therapeutic effects through a variety of pathways, attracting great interest and playing a vital role in the treatment of MetS and CVDs. Consequently, in this article, we aim to review the pharmacological actions and potential mechanisms of OA in treating MetS and related CVDs. |
| first_indexed | 2024-03-07T22:19:57Z |
| format | Article |
| id | doaj.art-82a0e94ca3c3480ab5153b070b8b02d9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-07T22:19:57Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-82a0e94ca3c3480ab5153b070b8b02d92024-02-23T15:28:48ZengMDPI AGMolecules1420-30492024-02-0129475810.3390/molecules29040758The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular DiseasesQuanye Luo0Yu Wei1Xuzhen Lv2Wen Chen3Dongmei Yang4Qinhui Tuo5Key Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, ChinaKey Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, ChinaKey Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, The School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, ChinaKey Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, ChinaKey Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, ChinaKey Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, ChinaMetabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia, and hypertension, which increase the risk of CVDs’ initiation and development. Although there are many availabile drugs for treating MetS and related CVDs, some side effects also occur. Considering the low-level side effects, many natural products have been tried to treat MetS and CVDs. A five-cyclic triterpenoid natural product, oleanolic acid (OA), has been reported to have many pharmacologic actions such as anti-hypertension, anti-hyperlipidemia, and liver protection. OA has specific advantages in the treatment of MetS and CVDs. OA achieves therapeutic effects through a variety of pathways, attracting great interest and playing a vital role in the treatment of MetS and CVDs. Consequently, in this article, we aim to review the pharmacological actions and potential mechanisms of OA in treating MetS and related CVDs.https://www.mdpi.com/1420-3049/29/4/758oleanolic acidmetabolic syndromecardiovascular diseases |
| spellingShingle | Quanye Luo Yu Wei Xuzhen Lv Wen Chen Dongmei Yang Qinhui Tuo The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases Molecules oleanolic acid metabolic syndrome cardiovascular diseases |
| title | The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases |
| title_full | The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases |
| title_fullStr | The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases |
| title_full_unstemmed | The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases |
| title_short | The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases |
| title_sort | effect and mechanism of oleanolic acid in the treatment of metabolic syndrome and related cardiovascular diseases |
| topic | oleanolic acid metabolic syndrome cardiovascular diseases |
| url | https://www.mdpi.com/1420-3049/29/4/758 |
| work_keys_str_mv | AT quanyeluo theeffectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases AT yuwei theeffectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases AT xuzhenlv theeffectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases AT wenchen theeffectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases AT dongmeiyang theeffectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases AT qinhuituo theeffectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases AT quanyeluo effectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases AT yuwei effectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases AT xuzhenlv effectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases AT wenchen effectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases AT dongmeiyang effectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases AT qinhuituo effectandmechanismofoleanolicacidinthetreatmentofmetabolicsyndromeandrelatedcardiovasculardiseases |