Localized amyloidosis of the epididymis: a previously unreported phenomenon

Abstract Background Localized amyloidosis has not been documented in the epididymis; we report this phenomenon for the first time. Case presentation The first aim of this work is to report three cases of localized epididymal amyloidosis. Two cases were clinically detected as epididymal nodules, and...

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Main Authors: Lucio Díaz-Flores, Ricardo Gutiérrez, Ma. del Pino García, Manuel Jose Gayoso, Jose Luis Carrasco, Hugo Álvarez-Argüelles
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Diagnostic Pathology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13000-017-0646-z
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author Lucio Díaz-Flores
Ricardo Gutiérrez
Ma. del Pino García
Manuel Jose Gayoso
Jose Luis Carrasco
Lucio Díaz-Flores
Hugo Álvarez-Argüelles
author_facet Lucio Díaz-Flores
Ricardo Gutiérrez
Ma. del Pino García
Manuel Jose Gayoso
Jose Luis Carrasco
Lucio Díaz-Flores
Hugo Álvarez-Argüelles
author_sort Lucio Díaz-Flores
collection DOAJ
description Abstract Background Localized amyloidosis has not been documented in the epididymis; we report this phenomenon for the first time. Case presentation The first aim of this work is to report three cases of localized epididymal amyloidosis. Two cases were clinically detected as epididymal nodules, and a third after reviewing 120 epididymides obtained with neighbouring pathological processes. Amyloid deposits showed Congo red positivity, with yellow-green birefringence, and immunohistochemical expression for light chains kappa and lambda, transthyretin, amyloid P and cytokeratin AE1 AE3. No immunoreactivity for amyloid A was seen. Amyloid deposit location was intraluminal, with partial or total loss of the epididymal epithelium and subsequent passage to the interstitium, forming large masses. No amyloid deposits were observed around blood vessels. A secondary objective was to explore in normal epididymis the amyloid tested in epididymal amyloidosis. In normal epididymides, expression of amyloid P and transthyretin was detected in the apical surface of epithelial cells. Amyloid P also showed strong expression in spermatozoa. Conclusion We contribute the existence of localized epididymal amyloidosis, which presents a distinctive, initial intratubular location, where there is a unique proteome and where functional amyloids act during sperm maturation.
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spelling doaj.art-82a16e26fd7a4855b4ee5d461070a2ec2022-12-21T22:38:47ZengBMCDiagnostic Pathology1746-15962017-08-011211710.1186/s13000-017-0646-zLocalized amyloidosis of the epididymis: a previously unreported phenomenonLucio Díaz-Flores0Ricardo Gutiérrez1Ma. del Pino García2Manuel Jose Gayoso3Jose Luis Carrasco4Lucio Díaz-Flores5Hugo Álvarez-Argüelles6Department of Basic Medical Sciences, Faculty of Medicine, University of La LagunaDepartment of Basic Medical Sciences, Faculty of Medicine, University of La LagunaDepartment of Pathology, Hospiten® HospitalsDepartment of Cell Biology and Pharmacology, Faculty of Medicine, University of ValladolidDepartment of Basic Medical Sciences, Faculty of Medicine, University of La LagunaDepartment of Basic Medical Sciences, Faculty of Medicine, University of La LagunaDepartment of Basic Medical Sciences, Faculty of Medicine, University of La LagunaAbstract Background Localized amyloidosis has not been documented in the epididymis; we report this phenomenon for the first time. Case presentation The first aim of this work is to report three cases of localized epididymal amyloidosis. Two cases were clinically detected as epididymal nodules, and a third after reviewing 120 epididymides obtained with neighbouring pathological processes. Amyloid deposits showed Congo red positivity, with yellow-green birefringence, and immunohistochemical expression for light chains kappa and lambda, transthyretin, amyloid P and cytokeratin AE1 AE3. No immunoreactivity for amyloid A was seen. Amyloid deposit location was intraluminal, with partial or total loss of the epididymal epithelium and subsequent passage to the interstitium, forming large masses. No amyloid deposits were observed around blood vessels. A secondary objective was to explore in normal epididymis the amyloid tested in epididymal amyloidosis. In normal epididymides, expression of amyloid P and transthyretin was detected in the apical surface of epithelial cells. Amyloid P also showed strong expression in spermatozoa. Conclusion We contribute the existence of localized epididymal amyloidosis, which presents a distinctive, initial intratubular location, where there is a unique proteome and where functional amyloids act during sperm maturation.http://link.springer.com/article/10.1186/s13000-017-0646-zEpididymisAmyloidAmyloidosis
spellingShingle Lucio Díaz-Flores
Ricardo Gutiérrez
Ma. del Pino García
Manuel Jose Gayoso
Jose Luis Carrasco
Lucio Díaz-Flores
Hugo Álvarez-Argüelles
Localized amyloidosis of the epididymis: a previously unreported phenomenon
Diagnostic Pathology
Epididymis
Amyloid
Amyloidosis
title Localized amyloidosis of the epididymis: a previously unreported phenomenon
title_full Localized amyloidosis of the epididymis: a previously unreported phenomenon
title_fullStr Localized amyloidosis of the epididymis: a previously unreported phenomenon
title_full_unstemmed Localized amyloidosis of the epididymis: a previously unreported phenomenon
title_short Localized amyloidosis of the epididymis: a previously unreported phenomenon
title_sort localized amyloidosis of the epididymis a previously unreported phenomenon
topic Epididymis
Amyloid
Amyloidosis
url http://link.springer.com/article/10.1186/s13000-017-0646-z
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