Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia
<h4>Objective</h4> Alternating Hemiplegia of Childhood (AHC) is characterised by paroxysmal hemiplegic episodes and seizures. Remission of hemiplegia upon sleep is a clinical diagnostic feature of AHC. We investigated whether: 1) Hemiplegic events are associated with spectral EEG changes...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524638/?tool=EBI |
| _version_ | 1811181741376798720 |
|---|---|
| author | Josephine Poole Sara Zagaglia Rita Demurtas Fiona Farrell Matthew C. Walker Sanjay M. Sisodiya Simona Balestrini Umesh Vivekananda |
| author_facet | Josephine Poole Sara Zagaglia Rita Demurtas Fiona Farrell Matthew C. Walker Sanjay M. Sisodiya Simona Balestrini Umesh Vivekananda |
| author_sort | Josephine Poole |
| collection | DOAJ |
| description | <h4>Objective</h4> Alternating Hemiplegia of Childhood (AHC) is characterised by paroxysmal hemiplegic episodes and seizures. Remission of hemiplegia upon sleep is a clinical diagnostic feature of AHC. We investigated whether: 1) Hemiplegic events are associated with spectral EEG changes 2) Sleep in AHC is associated with clinical or EEG spectral features that may explain its restorative effect. <h4>Methods</h4> We retrospectively performed EEG spectral analysis in five adults with AHC and twelve age-/gender-matched epilepsy controls. Five-minute epochs of hemiplegic episodes and ten-minute epochs of four sleep stages were selected from video-EEGs. Arousals were counted per hour of sleep. <h4>Results</h4> We found 1) hemispheric differences in pre-ictal and ictal spectral power (p = 0.034), during AHC hemiplegic episodes 2) 22% reduced beta power (p = 0.017) and 26% increased delta power (p = 0.025) during wakefulness in AHC versus controls. There were 98% more arousals in the AHC group versus controls (p = 0.0003). <h4>Conclusions</h4> There are hemispheric differences in spectral power preceding hemiplegic episodes in adults with AHC, and sleep is disrupted. <h4>Significance</h4> Spectral EEG changes may be a potential predictive tool for AHC hemiplegic episodes. Significantly disrupted sleep is a feature of AHC. |
| first_indexed | 2024-04-11T09:22:41Z |
| format | Article |
| id | doaj.art-82a21a318ab34c71a5c1c650080881ef |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T09:22:41Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-82a21a318ab34c71a5c1c650080881ef2022-12-22T04:32:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegiaJosephine PooleSara ZagagliaRita DemurtasFiona FarrellMatthew C. WalkerSanjay M. SisodiyaSimona BalestriniUmesh Vivekananda<h4>Objective</h4> Alternating Hemiplegia of Childhood (AHC) is characterised by paroxysmal hemiplegic episodes and seizures. Remission of hemiplegia upon sleep is a clinical diagnostic feature of AHC. We investigated whether: 1) Hemiplegic events are associated with spectral EEG changes 2) Sleep in AHC is associated with clinical or EEG spectral features that may explain its restorative effect. <h4>Methods</h4> We retrospectively performed EEG spectral analysis in five adults with AHC and twelve age-/gender-matched epilepsy controls. Five-minute epochs of hemiplegic episodes and ten-minute epochs of four sleep stages were selected from video-EEGs. Arousals were counted per hour of sleep. <h4>Results</h4> We found 1) hemispheric differences in pre-ictal and ictal spectral power (p = 0.034), during AHC hemiplegic episodes 2) 22% reduced beta power (p = 0.017) and 26% increased delta power (p = 0.025) during wakefulness in AHC versus controls. There were 98% more arousals in the AHC group versus controls (p = 0.0003). <h4>Conclusions</h4> There are hemispheric differences in spectral power preceding hemiplegic episodes in adults with AHC, and sleep is disrupted. <h4>Significance</h4> Spectral EEG changes may be a potential predictive tool for AHC hemiplegic episodes. Significantly disrupted sleep is a feature of AHC.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524638/?tool=EBI |
| spellingShingle | Josephine Poole Sara Zagaglia Rita Demurtas Fiona Farrell Matthew C. Walker Sanjay M. Sisodiya Simona Balestrini Umesh Vivekananda Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia PLoS ONE |
| title | Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia |
| title_full | Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia |
| title_fullStr | Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia |
| title_full_unstemmed | Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia |
| title_short | Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia |
| title_sort | alternating hemiplegia of childhood an electroclinical study of sleep and hemiplegia |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524638/?tool=EBI |
| work_keys_str_mv | AT josephinepoole alternatinghemiplegiaofchildhoodanelectroclinicalstudyofsleepandhemiplegia AT sarazagaglia alternatinghemiplegiaofchildhoodanelectroclinicalstudyofsleepandhemiplegia AT ritademurtas alternatinghemiplegiaofchildhoodanelectroclinicalstudyofsleepandhemiplegia AT fionafarrell alternatinghemiplegiaofchildhoodanelectroclinicalstudyofsleepandhemiplegia AT matthewcwalker alternatinghemiplegiaofchildhoodanelectroclinicalstudyofsleepandhemiplegia AT sanjaymsisodiya alternatinghemiplegiaofchildhoodanelectroclinicalstudyofsleepandhemiplegia AT simonabalestrini alternatinghemiplegiaofchildhoodanelectroclinicalstudyofsleepandhemiplegia AT umeshvivekananda alternatinghemiplegiaofchildhoodanelectroclinicalstudyofsleepandhemiplegia |