Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy
Appendiceal cancer treatment may include cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We investigated whether patient race/ethnicity influences outcomes and overall survival for patients with appendiceal cancer who undergo CRS/HIPEC. We queried the National Cancer...
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MDPI AG
2023-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/15/3990 |
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| author | Devon C. Freudenberger Vignesh Vudatha Luke G. Wolfe Andrea N. Riner Kelly M. Herremans Brian K. Sparkman Leopoldo J. Fernandez Jose G. Trevino |
| author_facet | Devon C. Freudenberger Vignesh Vudatha Luke G. Wolfe Andrea N. Riner Kelly M. Herremans Brian K. Sparkman Leopoldo J. Fernandez Jose G. Trevino |
| author_sort | Devon C. Freudenberger |
| collection | DOAJ |
| description | Appendiceal cancer treatment may include cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We investigated whether patient race/ethnicity influences outcomes and overall survival for patients with appendiceal cancer who undergo CRS/HIPEC. We queried the National Cancer Database for adult patients with appendiceal cancer treated with CRS/HIPEC from 2006 to 2018. Patients were stratified by race/ethnicity: non-Hispanic White (NHW), non-Hispanic Black (NHB), Hispanic, and Other. Sociodemographics and outcomes were compared using descriptive statistics. Kaplan–Meier survival analysis and Log-rank tests assessed differences in overall survival (OS). Cox Multivariate Regression evaluated factors associated with OS. In total, 2532 patients were identified: 2098 (82.9%) NHW, 186 (7.3%) NHB, 127 (5.0%) Hispanic, and 121 (4.8%) Other patients. The sociodemographics were statistically different across groups. The perioperative and postoperative outcomes were similar. OS was significantly different by race/ethnicity (<i>p</i> = 0.0029). NHB patients compared to Hispanic patients had the shortest median OS (106.7 vs. 145.9 months, <i>p</i> = 0.0093). Race/ethnicity was independently associated with OS: NHB (HR: 2.117 [1.306, 3.431], <i>p</i> = 0.0023) and NHW (HR: 1.549 [1.007, 2.383], <i>p</i> = 0.0463) patients compared to Hispanic patients had worse survival rates. Racial/ethnic disparities exist for patients with appendiceal cancer undergoing CRS/HIPEC. Despite having similar tumor and treatment characteristics, OS is associated with patient race/ethnicity. |
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| id | doaj.art-82a2a23fa65a479f879112c8249a4d97 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:30:30Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-82a2a23fa65a479f879112c8249a4d972023-11-18T22:44:08ZengMDPI AGCancers2072-66942023-08-011515399010.3390/cancers15153990Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal ChemotherapyDevon C. Freudenberger0Vignesh Vudatha1Luke G. Wolfe2Andrea N. Riner3Kelly M. Herremans4Brian K. Sparkman5Leopoldo J. Fernandez6Jose G. Trevino7Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USADepartment of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USADepartment of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USADepartment of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USADepartment of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USADepartment of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USADepartment of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USADepartment of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USAAppendiceal cancer treatment may include cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We investigated whether patient race/ethnicity influences outcomes and overall survival for patients with appendiceal cancer who undergo CRS/HIPEC. We queried the National Cancer Database for adult patients with appendiceal cancer treated with CRS/HIPEC from 2006 to 2018. Patients were stratified by race/ethnicity: non-Hispanic White (NHW), non-Hispanic Black (NHB), Hispanic, and Other. Sociodemographics and outcomes were compared using descriptive statistics. Kaplan–Meier survival analysis and Log-rank tests assessed differences in overall survival (OS). Cox Multivariate Regression evaluated factors associated with OS. In total, 2532 patients were identified: 2098 (82.9%) NHW, 186 (7.3%) NHB, 127 (5.0%) Hispanic, and 121 (4.8%) Other patients. The sociodemographics were statistically different across groups. The perioperative and postoperative outcomes were similar. OS was significantly different by race/ethnicity (<i>p</i> = 0.0029). NHB patients compared to Hispanic patients had the shortest median OS (106.7 vs. 145.9 months, <i>p</i> = 0.0093). Race/ethnicity was independently associated with OS: NHB (HR: 2.117 [1.306, 3.431], <i>p</i> = 0.0023) and NHW (HR: 1.549 [1.007, 2.383], <i>p</i> = 0.0463) patients compared to Hispanic patients had worse survival rates. Racial/ethnic disparities exist for patients with appendiceal cancer undergoing CRS/HIPEC. Despite having similar tumor and treatment characteristics, OS is associated with patient race/ethnicity.https://www.mdpi.com/2072-6694/15/15/3990appendiceal cancercytoreductive surgery (CRS)hyperthermic intraperitoneal chemotherapy (HIPEC)racial disparitiescancer survivorship |
| spellingShingle | Devon C. Freudenberger Vignesh Vudatha Luke G. Wolfe Andrea N. Riner Kelly M. Herremans Brian K. Sparkman Leopoldo J. Fernandez Jose G. Trevino Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy Cancers appendiceal cancer cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC) racial disparities cancer survivorship |
| title | Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy |
| title_full | Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy |
| title_fullStr | Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy |
| title_full_unstemmed | Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy |
| title_short | Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy |
| title_sort | race and ethnicity impacts overall survival of patients with appendiceal cancer who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy |
| topic | appendiceal cancer cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC) racial disparities cancer survivorship |
| url | https://www.mdpi.com/2072-6694/15/15/3990 |
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