Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial
"n Objective: "n "nThe objective of this study was to assess the efficacy and safety of SX (combination of yohimbine and L-arginine) in the treatment of erectile dysfunction (ED). "nMethods: This trial was a 4-week, double blind study of parallel groups of patients with mild to m...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2010-05-01
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| Series: | Iranian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/15564.pdf&manuscript_id=15564 |
| _version_ | 1818646050955591680 |
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| author | Amir Houshang Bagher Afshar Amir Shahin Akhondzadeh |
| author_facet | Amir Houshang Bagher Afshar Amir Shahin Akhondzadeh |
| author_sort | Amir Houshang Bagher |
| collection | DOAJ |
| description | "n Objective: "n "nThe objective of this study was to assess the efficacy and safety of SX (combination of yohimbine and L-arginine) in the treatment of erectile dysfunction (ED). "nMethods: This trial was a 4-week, double blind study of parallel groups of patients with mild to moderate ED. Forty married male patients with ED of mild-to-moderate severity were screened for the study entry ;among them, those aged 25-50 who reported a minimum of a- 3-month history of ED were eligible to enroll in this study. The severity of ED was based on EF domain scores on the international index of erectile function (IIEF). The scores of 15- 25 was considered as mild to moderate ED. Patients were randomized to receive one capsule of SX or placebo on demand in a 1:1 ratio using a computer-generated code. "nResults: The difference between the two groups was significant at week 4 (endpoint) (P=0.03). Four adverse events were observed over the study. The difference between the SX and placebo was not significant in the frequency of adverse events. "nConclusion: This study indicates that SX is safe and effective for the treatment of mild to moderate ED at least in the short-term. |
| first_indexed | 2024-12-17T00:40:29Z |
| format | Article |
| id | doaj.art-82a32f38a40b46468cb540618c31f749 |
| institution | Directory Open Access Journal |
| issn | 1735-4587 2008-2215 |
| language | English |
| last_indexed | 2024-12-17T00:40:29Z |
| publishDate | 2010-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Psychiatry |
| spelling | doaj.art-82a32f38a40b46468cb540618c31f7492022-12-21T22:10:02ZengTehran University of Medical SciencesIranian Journal of Psychiatry1735-45872008-22152010-05-015113Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trialAmir Houshang BagherAfshar AmirShahin Akhondzadeh"n Objective: "n "nThe objective of this study was to assess the efficacy and safety of SX (combination of yohimbine and L-arginine) in the treatment of erectile dysfunction (ED). "nMethods: This trial was a 4-week, double blind study of parallel groups of patients with mild to moderate ED. Forty married male patients with ED of mild-to-moderate severity were screened for the study entry ;among them, those aged 25-50 who reported a minimum of a- 3-month history of ED were eligible to enroll in this study. The severity of ED was based on EF domain scores on the international index of erectile function (IIEF). The scores of 15- 25 was considered as mild to moderate ED. Patients were randomized to receive one capsule of SX or placebo on demand in a 1:1 ratio using a computer-generated code. "nResults: The difference between the two groups was significant at week 4 (endpoint) (P=0.03). Four adverse events were observed over the study. The difference between the SX and placebo was not significant in the frequency of adverse events. "nConclusion: This study indicates that SX is safe and effective for the treatment of mild to moderate ED at least in the short-term.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/15564.pdf&manuscript_id=15564Erectile DysfunctionL-ArginineYohimbine |
| spellingShingle | Amir Houshang Bagher Afshar Amir Shahin Akhondzadeh Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial Iranian Journal of Psychiatry Erectile Dysfunction L-Arginine Yohimbine |
| title | Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial |
| title_full | Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial |
| title_fullStr | Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial |
| title_full_unstemmed | Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial |
| title_short | Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial |
| title_sort | efficacy and safety of oral combination of yohimbine and l arginine sx for the treatment of erectile dysfunction a multicenter randomized double blind placebo controlled clinical trial |
| topic | Erectile Dysfunction L-Arginine Yohimbine |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/15564.pdf&manuscript_id=15564 |
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