Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease
Hypertension is highly prevalent in chronic kidney disease (CKD). Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced gasotransmitter with vasodilator properties. We, hence, investigated whether oral administration of sodium thiosulfate (STS), a clinically applicable H<sub&g...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/1/147 |
| _version_ | 1797496174937112576 |
|---|---|
| author | Chien-Ning Hsu Chih-Yao Hou Guo-Ping Chang-Chien Sufan Lin Hung-Wei Yang You-Lin Tain |
| author_facet | Chien-Ning Hsu Chih-Yao Hou Guo-Ping Chang-Chien Sufan Lin Hung-Wei Yang You-Lin Tain |
| author_sort | Chien-Ning Hsu |
| collection | DOAJ |
| description | Hypertension is highly prevalent in chronic kidney disease (CKD). Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced gasotransmitter with vasodilator properties. We, hence, investigated whether oral administration of sodium thiosulfate (STS), a clinically applicable H<sub>2</sub>S-based therapy, can exert a protective effect against hypertension in an adenine-induced CKD rat model. Eight-week-old male Sprague–Dawley rats were fed with 0.5% adenine chow for 3 weeks to induce CKD. After 1 week, the rats were divided into two groups: one without and one with STS (2 g/kg body weight/day) in drinking water for 2 weeks. Treatment with STS lowered systolic and diastolic blood pressure by 7 and 9 mm Hg, respectively. Renal H<sub>2</sub>S-generating enzyme expression was inhibited by CKD, while STS therapy increased plasma levels of H<sub>2</sub>S and thiosulfate. Additionally, restoration of nitric oxide bioavailability and rebalance of the renin–angiotensin system may contribute to the protective effects of STS. Our data suggest that the oral administration of STS improves hypertension in an adenine-induced CKD model, which brings us closer to the clinical translation of H<sub>2</sub>S-targeting therapy in CKD-induced hypertension. |
| first_indexed | 2024-03-10T01:59:55Z |
| format | Article |
| id | doaj.art-82a41ee4b920476f97457fbd02267086 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T01:59:55Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-82a41ee4b920476f97457fbd022670862023-11-23T12:48:05ZengMDPI AGAntioxidants2076-39212022-01-0111114710.3390/antiox11010147Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney DiseaseChien-Ning Hsu0Chih-Yao Hou1Guo-Ping Chang-Chien2Sufan Lin3Hung-Wei Yang4You-Lin Tain5Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanDepartment of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 811, TaiwanCenter for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 833, TaiwanCenter for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 833, TaiwanInstitute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanHypertension is highly prevalent in chronic kidney disease (CKD). Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced gasotransmitter with vasodilator properties. We, hence, investigated whether oral administration of sodium thiosulfate (STS), a clinically applicable H<sub>2</sub>S-based therapy, can exert a protective effect against hypertension in an adenine-induced CKD rat model. Eight-week-old male Sprague–Dawley rats were fed with 0.5% adenine chow for 3 weeks to induce CKD. After 1 week, the rats were divided into two groups: one without and one with STS (2 g/kg body weight/day) in drinking water for 2 weeks. Treatment with STS lowered systolic and diastolic blood pressure by 7 and 9 mm Hg, respectively. Renal H<sub>2</sub>S-generating enzyme expression was inhibited by CKD, while STS therapy increased plasma levels of H<sub>2</sub>S and thiosulfate. Additionally, restoration of nitric oxide bioavailability and rebalance of the renin–angiotensin system may contribute to the protective effects of STS. Our data suggest that the oral administration of STS improves hypertension in an adenine-induced CKD model, which brings us closer to the clinical translation of H<sub>2</sub>S-targeting therapy in CKD-induced hypertension.https://www.mdpi.com/2076-3921/11/1/147symmetric dimethylargininechronic kidney diseasehydrogen sulfidehypertensionnitric oxiderenin–angiotensin system |
| spellingShingle | Chien-Ning Hsu Chih-Yao Hou Guo-Ping Chang-Chien Sufan Lin Hung-Wei Yang You-Lin Tain Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease Antioxidants symmetric dimethylarginine chronic kidney disease hydrogen sulfide hypertension nitric oxide renin–angiotensin system |
| title | Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease |
| title_full | Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease |
| title_fullStr | Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease |
| title_full_unstemmed | Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease |
| title_short | Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease |
| title_sort | sodium thiosulfate improves hypertension in rats with adenine induced chronic kidney disease |
| topic | symmetric dimethylarginine chronic kidney disease hydrogen sulfide hypertension nitric oxide renin–angiotensin system |
| url | https://www.mdpi.com/2076-3921/11/1/147 |
| work_keys_str_mv | AT chienninghsu sodiumthiosulfateimproveshypertensioninratswithadenineinducedchronickidneydisease AT chihyaohou sodiumthiosulfateimproveshypertensioninratswithadenineinducedchronickidneydisease AT guopingchangchien sodiumthiosulfateimproveshypertensioninratswithadenineinducedchronickidneydisease AT sufanlin sodiumthiosulfateimproveshypertensioninratswithadenineinducedchronickidneydisease AT hungweiyang sodiumthiosulfateimproveshypertensioninratswithadenineinducedchronickidneydisease AT youlintain sodiumthiosulfateimproveshypertensioninratswithadenineinducedchronickidneydisease |