Imprinted Long Non-Coding RNAs in Mammalian Development and Disease
Imprinted genes play diverse roles in mammalian development, homeostasis, and disease. Most imprinted chromosomal domains express one or more long non-coding RNAs (lncRNAs). Several of these lncRNAs are strictly nuclear and their mono-allelic expression controls in <i>cis</i> the express...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/17/13647 |
| _version_ | 1797582331802812416 |
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| author | Flavio Di Michele Isabel Chillón Robert Feil |
| author_facet | Flavio Di Michele Isabel Chillón Robert Feil |
| author_sort | Flavio Di Michele |
| collection | DOAJ |
| description | Imprinted genes play diverse roles in mammalian development, homeostasis, and disease. Most imprinted chromosomal domains express one or more long non-coding RNAs (lncRNAs). Several of these lncRNAs are strictly nuclear and their mono-allelic expression controls in <i>cis</i> the expression of protein-coding genes, often developmentally regulated. Some imprinted lncRNAs act in <i>trans</i> as well, controlling target gene expression elsewhere in the genome. The regulation of imprinted gene expression—including that of imprinted lncRNAs—is susceptible to stochastic and environmentally triggered epigenetic changes in the early embryo. These aberrant changes persist during subsequent development and have long-term phenotypic consequences. This review focuses on the expression and the <i>cis</i>- and <i>trans</i>-regulatory roles of imprinted lncRNAs and describes human disease syndromes associated with their perturbed expression. |
| first_indexed | 2024-03-10T23:20:33Z |
| format | Article |
| id | doaj.art-82a48636d4a4465e9cbdbec0fe7b9fa9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:20:33Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-82a48636d4a4465e9cbdbec0fe7b9fa92023-11-19T08:20:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124171364710.3390/ijms241713647Imprinted Long Non-Coding RNAs in Mammalian Development and DiseaseFlavio Di Michele0Isabel Chillón1Robert Feil2Institute of Molecular Genetics of Montpellier (IGMM), CNRS, 1919 Route de Mende, 34093 Montpellier, FranceInstitute of Molecular Genetics of Montpellier (IGMM), CNRS, 1919 Route de Mende, 34093 Montpellier, FranceInstitute of Molecular Genetics of Montpellier (IGMM), CNRS, 1919 Route de Mende, 34093 Montpellier, FranceImprinted genes play diverse roles in mammalian development, homeostasis, and disease. Most imprinted chromosomal domains express one or more long non-coding RNAs (lncRNAs). Several of these lncRNAs are strictly nuclear and their mono-allelic expression controls in <i>cis</i> the expression of protein-coding genes, often developmentally regulated. Some imprinted lncRNAs act in <i>trans</i> as well, controlling target gene expression elsewhere in the genome. The regulation of imprinted gene expression—including that of imprinted lncRNAs—is susceptible to stochastic and environmentally triggered epigenetic changes in the early embryo. These aberrant changes persist during subsequent development and have long-term phenotypic consequences. This review focuses on the expression and the <i>cis</i>- and <i>trans</i>-regulatory roles of imprinted lncRNAs and describes human disease syndromes associated with their perturbed expression.https://www.mdpi.com/1422-0067/24/17/13647epigeneticsgenomic imprintinglong non-coding RNAtranscriptional interferencechromatin repressionhistone methylation |
| spellingShingle | Flavio Di Michele Isabel Chillón Robert Feil Imprinted Long Non-Coding RNAs in Mammalian Development and Disease International Journal of Molecular Sciences epigenetics genomic imprinting long non-coding RNA transcriptional interference chromatin repression histone methylation |
| title | Imprinted Long Non-Coding RNAs in Mammalian Development and Disease |
| title_full | Imprinted Long Non-Coding RNAs in Mammalian Development and Disease |
| title_fullStr | Imprinted Long Non-Coding RNAs in Mammalian Development and Disease |
| title_full_unstemmed | Imprinted Long Non-Coding RNAs in Mammalian Development and Disease |
| title_short | Imprinted Long Non-Coding RNAs in Mammalian Development and Disease |
| title_sort | imprinted long non coding rnas in mammalian development and disease |
| topic | epigenetics genomic imprinting long non-coding RNA transcriptional interference chromatin repression histone methylation |
| url | https://www.mdpi.com/1422-0067/24/17/13647 |
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