The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo
Total tannins from Punica granatum L (TPG) was obtained by aqueous-acetone extraction and was abundant in punicalagin and ellagic acid. As these compounds are known to act against inflammation and oxidative stress in synergistic fashion, this study was to investigate the protective role of TPG on th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646461930204X |
| _version_ | 1818920063988662272 |
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| author | Qiaoling Li Jie Tu Benhong Zhou |
| author_facet | Qiaoling Li Jie Tu Benhong Zhou |
| author_sort | Qiaoling Li |
| collection | DOAJ |
| description | Total tannins from Punica granatum L (TPG) was obtained by aqueous-acetone extraction and was abundant in punicalagin and ellagic acid. As these compounds are known to act against inflammation and oxidative stress in synergistic fashion, this study was to investigate the protective role of TPG on the kidney in focal segmental glomerulosclerosis (FSGS) rats. In the present study, the glomerulosclerosis model was established by nephrectomy and injection of Adriamycin. The rats were treated with TPG and benazepril (BEN) for nine weeks. The results revealed that TPG and BEN pretreatment produced a significant improvement in biochemical parameters and renal pathology, and reduced the expression of PDGF, a-SMA and Ang-II. Similarly, the PCR and protein expression results showed that TPG normalized the renal expression of TGF-β1/Smad in FSGS conditions. These results suggested that the molecular mechanism of TPG ameliorated kidney injury might be associated with the inhibition of TGF-β1/Smad pathway. |
| first_indexed | 2024-12-20T01:15:48Z |
| format | Article |
| id | doaj.art-82a536358d584380bcda7f18a4b23165 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T01:15:48Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-82a536358d584380bcda7f18a4b231652022-12-21T19:58:34ZengElsevierJournal of Functional Foods1756-46462019-06-0157361372The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivoQiaoling Li0Jie Tu1Benhong Zhou2School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaThe Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, ChinaDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China; School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; Corresponding author at: Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China.Total tannins from Punica granatum L (TPG) was obtained by aqueous-acetone extraction and was abundant in punicalagin and ellagic acid. As these compounds are known to act against inflammation and oxidative stress in synergistic fashion, this study was to investigate the protective role of TPG on the kidney in focal segmental glomerulosclerosis (FSGS) rats. In the present study, the glomerulosclerosis model was established by nephrectomy and injection of Adriamycin. The rats were treated with TPG and benazepril (BEN) for nine weeks. The results revealed that TPG and BEN pretreatment produced a significant improvement in biochemical parameters and renal pathology, and reduced the expression of PDGF, a-SMA and Ang-II. Similarly, the PCR and protein expression results showed that TPG normalized the renal expression of TGF-β1/Smad in FSGS conditions. These results suggested that the molecular mechanism of TPG ameliorated kidney injury might be associated with the inhibition of TGF-β1/Smad pathway.http://www.sciencedirect.com/science/article/pii/S175646461930204XPunica granatum LTotal tanninsFocal segmental glomerulosclerosisTGF-β1/Smad |
| spellingShingle | Qiaoling Li Jie Tu Benhong Zhou The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo Journal of Functional Foods Punica granatum L Total tannins Focal segmental glomerulosclerosis TGF-β1/Smad |
| title | The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo |
| title_full | The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo |
| title_fullStr | The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo |
| title_full_unstemmed | The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo |
| title_short | The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo |
| title_sort | tannins from punica granatum l natural regulator of tgf β1 smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo |
| topic | Punica granatum L Total tannins Focal segmental glomerulosclerosis TGF-β1/Smad |
| url | http://www.sciencedirect.com/science/article/pii/S175646461930204X |
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