Associations of low-carbohydrate with mortality in chronic kidney disease
AbstractBackground Diet management is an effective way to retard the progression of chronic kidney disease (CKD). However, very few studies investigated the influence of carbohydrate intake on CKD patients. In this prospective cohort study, the associations between carbohydrate intake and all-cause...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2202284 |
| _version_ | 1797658441173434368 |
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| author | Qidong Ren Yangzhong Zhou Huiting Luo Gang Chen Yan Han Ke Zheng Yan Qin Xuemei Li |
| author_facet | Qidong Ren Yangzhong Zhou Huiting Luo Gang Chen Yan Han Ke Zheng Yan Qin Xuemei Li |
| author_sort | Qidong Ren |
| collection | DOAJ |
| description | AbstractBackground Diet management is an effective way to retard the progression of chronic kidney disease (CKD). However, very few studies investigated the influence of carbohydrate intake on CKD patients. In this prospective cohort study, the associations between carbohydrate intake and all-cause mortality were investigated in US adult CKD patients.Methods Multivariable Cox proportional hazard models and iso-caloric replacement analysis were used to investigate the associations between the macronutrients and the all-cause mortality risk. Total 3683 US adult CKD patients 20 years or older from the National Health and Nutrition Examination Survey (NHANES, 2003–2014) were analyzed (mean age ± SD, 62.4 ± 17.1; 56.5% female), of which 1082 participants with CKD died with a median follow-up time of 67 (IQR 36–99) months.Results Most macronutrients were non-linearly associated with all-cause mortality risk, including carbohydrates and sugar. Participants with CKD had lower mortality risk when consuming 30–45% energy from carbohydrates (average HR 0.76, 95%CI 0.62–0.93, compared with 60%), 5–20% energy from sugar (average HR 0.75, 95% CI 0.59–0.96 compared with 40%). Replacing the energy intake from carbohydrates with protein (up to 30%) and/or replacing the sugar with non-sugar carbohydrates (up to 55%) reduced the all-cause mortality risk, while the total energy intake remained constant.Conclusions Diet advice should be given according to the current diet status, and constituents of carbohydrates should also be taken into consideration. |
| first_indexed | 2024-03-11T18:00:08Z |
| format | Article |
| id | doaj.art-82a69406e800443cac52a8b6bf5c234f |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-03-11T18:00:08Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-82a69406e800443cac52a8b6bf5c234f2023-10-17T09:23:24ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2202284Associations of low-carbohydrate with mortality in chronic kidney diseaseQidong Ren0Yangzhong Zhou1Huiting Luo2Gang Chen3Yan Han4Ke Zheng5Yan Qin6Xuemei Li7Department of Nephrology, Peking Union Medical College Hospital, Beijing, P.R. ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Beijing, P.R. ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Beijing, P.R. ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Beijing, P.R. ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Beijing, P.R. ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Beijing, P.R. ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Beijing, P.R. ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Beijing, P.R. ChinaAbstractBackground Diet management is an effective way to retard the progression of chronic kidney disease (CKD). However, very few studies investigated the influence of carbohydrate intake on CKD patients. In this prospective cohort study, the associations between carbohydrate intake and all-cause mortality were investigated in US adult CKD patients.Methods Multivariable Cox proportional hazard models and iso-caloric replacement analysis were used to investigate the associations between the macronutrients and the all-cause mortality risk. Total 3683 US adult CKD patients 20 years or older from the National Health and Nutrition Examination Survey (NHANES, 2003–2014) were analyzed (mean age ± SD, 62.4 ± 17.1; 56.5% female), of which 1082 participants with CKD died with a median follow-up time of 67 (IQR 36–99) months.Results Most macronutrients were non-linearly associated with all-cause mortality risk, including carbohydrates and sugar. Participants with CKD had lower mortality risk when consuming 30–45% energy from carbohydrates (average HR 0.76, 95%CI 0.62–0.93, compared with 60%), 5–20% energy from sugar (average HR 0.75, 95% CI 0.59–0.96 compared with 40%). Replacing the energy intake from carbohydrates with protein (up to 30%) and/or replacing the sugar with non-sugar carbohydrates (up to 55%) reduced the all-cause mortality risk, while the total energy intake remained constant.Conclusions Diet advice should be given according to the current diet status, and constituents of carbohydrates should also be taken into consideration.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2202284Chronic kidney diseaselow carbohydrate dietmortality |
| spellingShingle | Qidong Ren Yangzhong Zhou Huiting Luo Gang Chen Yan Han Ke Zheng Yan Qin Xuemei Li Associations of low-carbohydrate with mortality in chronic kidney disease Renal Failure Chronic kidney disease low carbohydrate diet mortality |
| title | Associations of low-carbohydrate with mortality in chronic kidney disease |
| title_full | Associations of low-carbohydrate with mortality in chronic kidney disease |
| title_fullStr | Associations of low-carbohydrate with mortality in chronic kidney disease |
| title_full_unstemmed | Associations of low-carbohydrate with mortality in chronic kidney disease |
| title_short | Associations of low-carbohydrate with mortality in chronic kidney disease |
| title_sort | associations of low carbohydrate with mortality in chronic kidney disease |
| topic | Chronic kidney disease low carbohydrate diet mortality |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2202284 |
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