The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis
While genetic advances have successfully defined part of the complexity in Parkinson’s disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies typically include patients with earlier disease stages and exclude comorbidities, thus ignoring...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2018.00326/full |
| _version_ | 1818031492104716288 |
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| author | Geraldine Hipp Geraldine Hipp Michel Vaillant Nico J. Diederich Kirsten Roomp Venkata P. Satagopam Peter Banda Estelle Sandt Kathleen Mommaerts Kathleen Mommaerts Sabine K. Schmitz Laura Longhino Alexandra Schweicher Anne-Marie Hanff Béatrice Nicolai Pierre Kolber Pierre Kolber Dorothea Reiter Dorothea Reiter Lukas Pavelka Lukas Pavelka Sylvia Binck Sylvia Binck Claire Pauly Claire Pauly Lars Geffers Fay Betsou Manon Gantenbein Jochen Klucken Thomas Gasser Michele T. Hu Rudi Balling Rejko Krüger Rejko Krüger |
| author_facet | Geraldine Hipp Geraldine Hipp Michel Vaillant Nico J. Diederich Kirsten Roomp Venkata P. Satagopam Peter Banda Estelle Sandt Kathleen Mommaerts Kathleen Mommaerts Sabine K. Schmitz Laura Longhino Alexandra Schweicher Anne-Marie Hanff Béatrice Nicolai Pierre Kolber Pierre Kolber Dorothea Reiter Dorothea Reiter Lukas Pavelka Lukas Pavelka Sylvia Binck Sylvia Binck Claire Pauly Claire Pauly Lars Geffers Fay Betsou Manon Gantenbein Jochen Klucken Thomas Gasser Michele T. Hu Rudi Balling Rejko Krüger Rejko Krüger |
| author_sort | Geraldine Hipp |
| collection | DOAJ |
| description | While genetic advances have successfully defined part of the complexity in Parkinson’s disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies typically include patients with earlier disease stages and exclude comorbidities, thus ignoring a substantial part of the real-world PD population. To account for these limitations, we implemented the Luxembourg PD study as a comprehensive clinical, molecular and device-based approach including patients with typical PD and atypical parkinsonism, irrespective of their disease stage, age, comorbidities, or linguistic background. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, we implemented an open-source digital platform that can be harmonized with international PD cohort studies. Our interests also reflect Luxembourg-specific areas of PD research, including vision, gait, and cognition. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies. We provide evidence for the feasibility of such a cohort program with deep phenotyping and high quality biosampling on parkinsonism in an environment with structural specificities and alert the international research community to our willingness to collaborate with other centers. The combination of advanced clinical phenotyping approaches including device-based assessment will create a comprehensive assessment of the disease and its variants, its interaction with comorbidities and its progression. We envision the Luxembourg Parkinson’s study as an important research platform for defining early diagnosis and progression markers that translate into stratified treatment approaches. |
| first_indexed | 2024-12-10T05:52:20Z |
| format | Article |
| id | doaj.art-82a875ad5112420baca84d0418177753 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-10T05:52:20Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-82a875ad5112420baca84d04181777532022-12-22T02:00:00ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-10-011010.3389/fnagi.2018.00326408277The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early DiagnosisGeraldine Hipp0Geraldine Hipp1Michel Vaillant2Nico J. Diederich3Kirsten Roomp4Venkata P. Satagopam5Peter Banda6Estelle Sandt7Kathleen Mommaerts8Kathleen Mommaerts9Sabine K. Schmitz10Laura Longhino11Alexandra Schweicher12Anne-Marie Hanff13Béatrice Nicolai14Pierre Kolber15Pierre Kolber16Dorothea Reiter17Dorothea Reiter18Lukas Pavelka19Lukas Pavelka20Sylvia Binck21Sylvia Binck22Claire Pauly23Claire Pauly24Lars Geffers25Fay Betsou26Manon Gantenbein27Jochen Klucken28Thomas Gasser29Michele T. Hu30Rudi Balling31Rejko Krüger32Rejko Krüger33Clinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgCompetence Centre in Methodology and Statistics, Luxembourg Institute of Health, Strassen, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgBioinformatics Core, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur Alzette, LuxembourgBioinformatics Core, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur Alzette, LuxembourgBioinformatics Core, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur Alzette, LuxembourgIntegrated BioBank of Luxembourg, Dudelange, LuxembourgIntegrated BioBank of Luxembourg, Dudelange, LuxembourgDevelopmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur Alzette, LuxembourgClinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgClinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgClinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgClinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgClinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgClinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgClinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, LuxembourgIntegrated BioBank of Luxembourg, Dudelange, LuxembourgClinical and Epidemiological Investigation Center, Luxembourg Institute of Health, Strassen, LuxembourgDepartment of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, GermanyDepartment of Neurodegeneration, Hertie-Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, Tübingen, Germany0Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, United KingdomClinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, LuxembourgClinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, LuxembourgNeurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgWhile genetic advances have successfully defined part of the complexity in Parkinson’s disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies typically include patients with earlier disease stages and exclude comorbidities, thus ignoring a substantial part of the real-world PD population. To account for these limitations, we implemented the Luxembourg PD study as a comprehensive clinical, molecular and device-based approach including patients with typical PD and atypical parkinsonism, irrespective of their disease stage, age, comorbidities, or linguistic background. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, we implemented an open-source digital platform that can be harmonized with international PD cohort studies. Our interests also reflect Luxembourg-specific areas of PD research, including vision, gait, and cognition. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies. We provide evidence for the feasibility of such a cohort program with deep phenotyping and high quality biosampling on parkinsonism in an environment with structural specificities and alert the international research community to our willingness to collaborate with other centers. The combination of advanced clinical phenotyping approaches including device-based assessment will create a comprehensive assessment of the disease and its variants, its interaction with comorbidities and its progression. We envision the Luxembourg Parkinson’s study as an important research platform for defining early diagnosis and progression markers that translate into stratified treatment approaches.https://www.frontiersin.org/article/10.3389/fnagi.2018.00326/fullparkinsonismcohortlongitudinalstratificationdeep phenotyping |
| spellingShingle | Geraldine Hipp Geraldine Hipp Michel Vaillant Nico J. Diederich Kirsten Roomp Venkata P. Satagopam Peter Banda Estelle Sandt Kathleen Mommaerts Kathleen Mommaerts Sabine K. Schmitz Laura Longhino Alexandra Schweicher Anne-Marie Hanff Béatrice Nicolai Pierre Kolber Pierre Kolber Dorothea Reiter Dorothea Reiter Lukas Pavelka Lukas Pavelka Sylvia Binck Sylvia Binck Claire Pauly Claire Pauly Lars Geffers Fay Betsou Manon Gantenbein Jochen Klucken Thomas Gasser Michele T. Hu Rudi Balling Rejko Krüger Rejko Krüger The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis Frontiers in Aging Neuroscience parkinsonism cohort longitudinal stratification deep phenotyping |
| title | The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis |
| title_full | The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis |
| title_fullStr | The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis |
| title_full_unstemmed | The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis |
| title_short | The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis |
| title_sort | luxembourg parkinson s study a comprehensive approach for stratification and early diagnosis |
| topic | parkinsonism cohort longitudinal stratification deep phenotyping |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2018.00326/full |
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