Versatile Flexible Graphene Multielectrode Arrays
Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocomp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-12-01
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| Series: | Biosensors |
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| Online Access: | http://www.mdpi.com/2079-6374/7/1/1 |
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| author | Dmitry Kireev Silke Seyock Mathis Ernst Vanessa Maybeck Bernhard Wolfrum Andreas Offenhäusser |
| author_facet | Dmitry Kireev Silke Seyock Mathis Ernst Vanessa Maybeck Bernhard Wolfrum Andreas Offenhäusser |
| author_sort | Dmitry Kireev |
| collection | DOAJ |
| description | Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells. Considering the low noise and excellent robustness of the devices, the sensor arrays are suitable for diverse and biologically relevant applications. |
| first_indexed | 2024-12-24T00:45:38Z |
| format | Article |
| id | doaj.art-82a9941d65df4d9fa50ff24aba233fd9 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-12-24T00:45:38Z |
| publishDate | 2016-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-82a9941d65df4d9fa50ff24aba233fd92022-12-21T17:23:49ZengMDPI AGBiosensors2079-63742016-12-0171110.3390/bios7010001bios7010001Versatile Flexible Graphene Multielectrode ArraysDmitry Kireev0Silke Seyock1Mathis Ernst2Vanessa Maybeck3Bernhard Wolfrum4Andreas Offenhäusser5Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, GermanyGraphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells. Considering the low noise and excellent robustness of the devices, the sensor arrays are suitable for diverse and biologically relevant applications.http://www.mdpi.com/2079-6374/7/1/1grapheneGMEAgraphene electrodesextracellular recordingscell-graphene interface |
| spellingShingle | Dmitry Kireev Silke Seyock Mathis Ernst Vanessa Maybeck Bernhard Wolfrum Andreas Offenhäusser Versatile Flexible Graphene Multielectrode Arrays Biosensors graphene GMEA graphene electrodes extracellular recordings cell-graphene interface |
| title | Versatile Flexible Graphene Multielectrode Arrays |
| title_full | Versatile Flexible Graphene Multielectrode Arrays |
| title_fullStr | Versatile Flexible Graphene Multielectrode Arrays |
| title_full_unstemmed | Versatile Flexible Graphene Multielectrode Arrays |
| title_short | Versatile Flexible Graphene Multielectrode Arrays |
| title_sort | versatile flexible graphene multielectrode arrays |
| topic | graphene GMEA graphene electrodes extracellular recordings cell-graphene interface |
| url | http://www.mdpi.com/2079-6374/7/1/1 |
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