Gag-Pol processing during HIV-1 virion maturation: a systems biology approach.

Gag-Pol processing during HIV-1 virion maturation: a systems biology approach.

Proteolytic processing of Gag and Gag-Pol polyproteins by the viral protease (PR) is crucial for the production of infectious HIV-1, and inhibitors of the viral PR are an integral part of current antiretroviral therapy. The process has several layers of complexity (multiple cleavage sites and substr...

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Bibliographic Details
Main Authors: Balázs Könnyű, S Kashif Sadiq, Tamás Turányi, Rita Hírmondó, Barbara Müller, Hans-Georg Kräusslich, Peter V Coveney, Viktor Müller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3675044?pdf=render

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