Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions

Histone deacetylase 8 (HDAC8) is a member of class I histone deacetylases (HDACs) that catalyzes the deacetylation of both histone and non-histone proteins. Dysregulation and overexpression of HDAC8 are implicated in the development of various complex diseases, including cancer and neurodegenerative...

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Bibliographic Details
Main Authors: Mohammed Alrouji, Kumar Venkatesan, Mohammed S. Alshammari, Fahad A. Alhumaydhi, Sheeba Shafi, Sharaf E. Sharaf, Moyad Shahwan, Anas Shamsi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
neuropathological conditions
drug repurposing
small-molecule inhibitors
virtual screening
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1488585/full

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