Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and <i>Aldh1l1</i> Knockout Mice

Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and <i>Aldh1l1</i> Knockout Mice

ALDH1L1 (10-formyltetrahydrofolate dehydrogenase), an enzyme of folate metabolism, is highly expressed in the liver. It regulates the overall flux of folate-bound one-carbon groups by converting 10-formyltetrahydrofolate to tetrahydrofolate and CO<sub>2</sub> in a NADP<sup>+</su...

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Bibliographic Details
Main Authors: Jaspreet Sharma, Blake R. Rushing, Madeline S. Hall, Kristi L. Helke, Susan L. McRitchie, Natalia I. Krupenko, Susan J. Sumner, Sergey A. Krupenko
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Metabolites
Subjects:
<i>Aldh1l1</i> knockout
folate metabolism
untargeted metabolomics
dietary folate restriction
liver
plasma
Online Access:https://www.mdpi.com/2218-1989/12/5/454

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