Association between enteric dysmotility and GnRH antibodies: A meta-analysis
Background and aim: Recent studies reported a significant association between enteric dysmotility and GnRH antibodies, other studies reported no significant association. Therefore, we aimed to perform a meta-analysis to investigate and clarify the exact association between enteric dysmotility and Gn...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2023-10-01
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| Series: | Gastroenterology & Endoscopy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949752323000481 |
| _version_ | 1797235405654851584 |
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| author | Karam R. Motawea Noheir Ashraf Ibrahem Fathy Hassan Nesreen Elsayed Talat Rowan H. Elhalag Sarya Swed Abdulqadir J. Nashwan Agyad Bakkour Bisher Sawaf Ivan Cherrez-Ojeda Wael Hafez |
| author_facet | Karam R. Motawea Noheir Ashraf Ibrahem Fathy Hassan Nesreen Elsayed Talat Rowan H. Elhalag Sarya Swed Abdulqadir J. Nashwan Agyad Bakkour Bisher Sawaf Ivan Cherrez-Ojeda Wael Hafez |
| author_sort | Karam R. Motawea |
| collection | DOAJ |
| description | Background and aim: Recent studies reported a significant association between enteric dysmotility and GnRH antibodies, other studies reported no significant association. Therefore, we aimed to perform a meta-analysis to investigate and clarify the exact association between enteric dysmotility and GnRH antibodies. Methods: PubMed, Web of Science, and Scopus databases were searched. The inclusion criteria were any randomized control trials or observational studies that reported the level or prevalence of GnRH IgM or GnRH IgG antibodies in patients with enteric dysmotility matched with healthy controls. Exclusion criteria: Case reports, case series, reviews, editorials, and animal studies. RevMan software 5.4 was used to perform the meta-analysis. Results: After search of the literature, 4 studies were included in the meta-analysis with a total number of 469 individuals included in the study. The pooled analysis showed a statistically significant association between enteric dysmotility and increased prevalence of GnRH IgM antibodies compared with controls (RR = 4.47, 95% CI = 1.17 to 17.06, p-value = 0.03). Contrarily, no statistically significant association between enteric dysmotility and the levels of IgM antibodies as well as the prevalence of IgG antibodies was found compared with controls, (MD = 0.92, 95% CI = -1.01 to 2.86, p-value = 0.35) and (RR = 1.84, 95% CI = 0.09 to 35.86, p-value = 0.69), respectively. Conclusion: Our study detected a significant association between intestinal dysmotility and high prevalence of GnRH IgM antibodies when matched with controls. Conversely, we found no statistically significant association between enteric dysmotility and IgG antibodies. Further research is warranted to support our results and clarify the exact association between enteric dysmotility and GnRH antibodies. |
| first_indexed | 2024-04-24T16:47:26Z |
| format | Article |
| id | doaj.art-82af194a9e0047c499736c803e905766 |
| institution | Directory Open Access Journal |
| issn | 2949-7523 |
| language | English |
| last_indexed | 2024-04-24T16:47:26Z |
| publishDate | 2023-10-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Gastroenterology & Endoscopy |
| spelling | doaj.art-82af194a9e0047c499736c803e9057662024-03-29T05:51:59ZengKeAi Communications Co., Ltd.Gastroenterology & Endoscopy2949-75232023-10-0114159164Association between enteric dysmotility and GnRH antibodies: A meta-analysisKaram R. Motawea0Noheir Ashraf Ibrahem Fathy Hassan1Nesreen Elsayed Talat2Rowan H. Elhalag3Sarya Swed4Abdulqadir J. Nashwan5Agyad Bakkour6Bisher Sawaf7Ivan Cherrez-Ojeda8Wael Hafez9Faculty of Medicine, Alexandria University, EgyptFaculty of Medicine, Aswan University, EgyptFaculty of Medicine, Alexandria University, EgyptFaculty of Medicine, Alexandria University, EgyptFaculty of Medicine, Aleppo University, Aleppo, SyriaNursing Department, Hamad Medical Corporation, Doha, Qatar; Corresponding author. P.O. Box 3050, Doha, Qatar.Faculty of Medicine, Albaath University, Homs, SyriaDepartment of Internal Medicine, Hamad Medical Corporation, Doha, QatarUniversidad Espíritu Santo, Samborondón, EcuadorNMC Royal Hospital, 16th Street, Khalifa City, Abu Dhabi, United Arab Emirates; Medical Research Division, Department of Internal Medicine, The National Research Centre, Cairo, EgyptBackground and aim: Recent studies reported a significant association between enteric dysmotility and GnRH antibodies, other studies reported no significant association. Therefore, we aimed to perform a meta-analysis to investigate and clarify the exact association between enteric dysmotility and GnRH antibodies. Methods: PubMed, Web of Science, and Scopus databases were searched. The inclusion criteria were any randomized control trials or observational studies that reported the level or prevalence of GnRH IgM or GnRH IgG antibodies in patients with enteric dysmotility matched with healthy controls. Exclusion criteria: Case reports, case series, reviews, editorials, and animal studies. RevMan software 5.4 was used to perform the meta-analysis. Results: After search of the literature, 4 studies were included in the meta-analysis with a total number of 469 individuals included in the study. The pooled analysis showed a statistically significant association between enteric dysmotility and increased prevalence of GnRH IgM antibodies compared with controls (RR = 4.47, 95% CI = 1.17 to 17.06, p-value = 0.03). Contrarily, no statistically significant association between enteric dysmotility and the levels of IgM antibodies as well as the prevalence of IgG antibodies was found compared with controls, (MD = 0.92, 95% CI = -1.01 to 2.86, p-value = 0.35) and (RR = 1.84, 95% CI = 0.09 to 35.86, p-value = 0.69), respectively. Conclusion: Our study detected a significant association between intestinal dysmotility and high prevalence of GnRH IgM antibodies when matched with controls. Conversely, we found no statistically significant association between enteric dysmotility and IgG antibodies. Further research is warranted to support our results and clarify the exact association between enteric dysmotility and GnRH antibodies.http://www.sciencedirect.com/science/article/pii/S2949752323000481Enteric dysmotilityGnRH antibodiesMeta-analysis |
| spellingShingle | Karam R. Motawea Noheir Ashraf Ibrahem Fathy Hassan Nesreen Elsayed Talat Rowan H. Elhalag Sarya Swed Abdulqadir J. Nashwan Agyad Bakkour Bisher Sawaf Ivan Cherrez-Ojeda Wael Hafez Association between enteric dysmotility and GnRH antibodies: A meta-analysis Gastroenterology & Endoscopy Enteric dysmotility GnRH antibodies Meta-analysis |
| title | Association between enteric dysmotility and GnRH antibodies: A meta-analysis |
| title_full | Association between enteric dysmotility and GnRH antibodies: A meta-analysis |
| title_fullStr | Association between enteric dysmotility and GnRH antibodies: A meta-analysis |
| title_full_unstemmed | Association between enteric dysmotility and GnRH antibodies: A meta-analysis |
| title_short | Association between enteric dysmotility and GnRH antibodies: A meta-analysis |
| title_sort | association between enteric dysmotility and gnrh antibodies a meta analysis |
| topic | Enteric dysmotility GnRH antibodies Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2949752323000481 |
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