Serum creatinine in predicting mortality after paraquat poisoning: A systematic review and meta-analysis
Although the prognostic value of blood creatinine levels in patients with paraquat (PQ) poisoning has been studied for a long time, the results are still controversial. Therefore, we performed the first meta-analysis to comprehensively assess the value of blood creatinine in predicting the prognosis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946265/?tool=EBI |
| _version_ | 1797894877861642240 |
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| author | Wei Huang Zheng Zhang Yuan-Qiang Lu |
| author_facet | Wei Huang Zheng Zhang Yuan-Qiang Lu |
| author_sort | Wei Huang |
| collection | DOAJ |
| description | Although the prognostic value of blood creatinine levels in patients with paraquat (PQ) poisoning has been studied for a long time, the results are still controversial. Therefore, we performed the first meta-analysis to comprehensively assess the value of blood creatinine in predicting the prognosis of patients with PQ poisoning. We searched PubMed, EMBase, Web of Science, ScienceDirect, Cochrane Library, China National Knowledge Infrastructure, China Science and Technology Journal Database, and China Online Journals to identify all relevant papers published up to June 2022. Data were extracted for pooled analysis, heterogeneity testing, sensitivity analysis, publication bias analysis, and subgroup analysis. Ultimately, 10 studies involving 862 patients were included. The I2 of diagnostic odds ratio (DOR), sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of this study were all greater than 50%, which showed the existence of heterogeneity in this study, and a random effects model was used for the combination of the above five effect sizes. Pooled analysis showed a high predictive value of blood creatinine for prognosis of PQ poisoning [pooled DOR:22.92, 95% confidence interval (CI):15.62–33.65, P < 0.001]. The combined sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were 86% (95% CI: 0.79–0.91), 78% (95% CI: 0.69–0.86), 4.01 (95% CI: 2.81–5.71), and 0.17 (95% CI: 0.12–0.25), respectively. Deeks publication bias test revealed there was publication bias. Sensitivity analysis showed no significant differences in the estimates of impact. Serum creatinine is an effective predictor of mortality in patients with PQ poisoning. |
| first_indexed | 2024-04-10T07:17:27Z |
| format | Article |
| id | doaj.art-82b0ca80363b47ed9bfb386066c0d31e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T07:17:27Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-82b0ca80363b47ed9bfb386066c0d31e2023-02-25T05:31:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01182Serum creatinine in predicting mortality after paraquat poisoning: A systematic review and meta-analysisWei HuangZheng ZhangYuan-Qiang LuAlthough the prognostic value of blood creatinine levels in patients with paraquat (PQ) poisoning has been studied for a long time, the results are still controversial. Therefore, we performed the first meta-analysis to comprehensively assess the value of blood creatinine in predicting the prognosis of patients with PQ poisoning. We searched PubMed, EMBase, Web of Science, ScienceDirect, Cochrane Library, China National Knowledge Infrastructure, China Science and Technology Journal Database, and China Online Journals to identify all relevant papers published up to June 2022. Data were extracted for pooled analysis, heterogeneity testing, sensitivity analysis, publication bias analysis, and subgroup analysis. Ultimately, 10 studies involving 862 patients were included. The I2 of diagnostic odds ratio (DOR), sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of this study were all greater than 50%, which showed the existence of heterogeneity in this study, and a random effects model was used for the combination of the above five effect sizes. Pooled analysis showed a high predictive value of blood creatinine for prognosis of PQ poisoning [pooled DOR:22.92, 95% confidence interval (CI):15.62–33.65, P < 0.001]. The combined sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were 86% (95% CI: 0.79–0.91), 78% (95% CI: 0.69–0.86), 4.01 (95% CI: 2.81–5.71), and 0.17 (95% CI: 0.12–0.25), respectively. Deeks publication bias test revealed there was publication bias. Sensitivity analysis showed no significant differences in the estimates of impact. Serum creatinine is an effective predictor of mortality in patients with PQ poisoning.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946265/?tool=EBI |
| spellingShingle | Wei Huang Zheng Zhang Yuan-Qiang Lu Serum creatinine in predicting mortality after paraquat poisoning: A systematic review and meta-analysis PLoS ONE |
| title | Serum creatinine in predicting mortality after paraquat poisoning: A systematic review and meta-analysis |
| title_full | Serum creatinine in predicting mortality after paraquat poisoning: A systematic review and meta-analysis |
| title_fullStr | Serum creatinine in predicting mortality after paraquat poisoning: A systematic review and meta-analysis |
| title_full_unstemmed | Serum creatinine in predicting mortality after paraquat poisoning: A systematic review and meta-analysis |
| title_short | Serum creatinine in predicting mortality after paraquat poisoning: A systematic review and meta-analysis |
| title_sort | serum creatinine in predicting mortality after paraquat poisoning a systematic review and meta analysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946265/?tool=EBI |
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