Allele-biased expression of the bovine APOB gene associated with the cholesterol deficiency defect suggests cis-regulatory enhancer effects of the LTR retrotransposon insertion

Allele-biased expression of the bovine APOB gene associated with the cholesterol deficiency defect suggests cis-regulatory enhancer effects of the LTR retrotransposon insertion

Abstract The insertion of an endogenous retroviral long terminal repeat (LTR) sequence into the bovine apolipoprotein B (APOB) gene is causal to the inherited genetic defect cholesterol deficiency (CD) observed in neonatal and young calves. Affected calves suffer from developmental abnormalities, sy...

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Bibliographic Details
Main Authors: Doreen Becker, Rosemarie Weikard, Annika Heimes, Frieder Hadlich, Harald M. Hammon, Marie M. Meyerholz, Wolfram Petzl, Holm Zerbe, Hans-Joachim Schuberth, Martina Hoedemaker, Marion Schmicke, Susanne Engelmann, Christa Kühn
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-17798-5

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