Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid
Bacterial infections have become a global issue that requires urgent attention, particularly regarding to emergence of multidrug resistant bacteria. We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain. Interest...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2018-06-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X17301214 |
| _version_ | 1797203646532812800 |
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| author | Mitra S. Ganewatta Md Anisur Rahman Louis Mercado Tinom Shokfai Alan W. Decho Theresa M. Reineke Chuanbing Tang |
| author_facet | Mitra S. Ganewatta Md Anisur Rahman Louis Mercado Tinom Shokfai Alan W. Decho Theresa M. Reineke Chuanbing Tang |
| author_sort | Mitra S. Ganewatta |
| collection | DOAJ |
| description | Bacterial infections have become a global issue that requires urgent attention, particularly regarding to emergence of multidrug resistant bacteria. We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain. Interestingly, by choosing appropriate monomers, these cationic polymers can form core-shell micelles. These polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial species. It is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial activities. Cytotoxicity assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers. |
| first_indexed | 2024-04-24T08:22:39Z |
| format | Article |
| id | doaj.art-82b71f5b66bf4d8fbd07423887327927 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:22:39Z |
| publishDate | 2018-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-82b71f5b66bf4d8fbd074238873279272024-04-17T00:33:59ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2018-06-013218619310.1016/j.bioactmat.2018.02.001Facially amphiphilic polyionene biocidal polymers derived from lithocholic acidMitra S. Ganewatta0Md Anisur Rahman1Louis Mercado2Tinom Shokfai3Alan W. Decho4Theresa M. Reineke5Chuanbing Tang6Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USADepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USADepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USADepartment of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USADepartment of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USADepartment of Chemistry, University of Minnesota - Twin Cities, 207 Pleasant Street SE, Minneapolis, MN 55455, USADepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USABacterial infections have become a global issue that requires urgent attention, particularly regarding to emergence of multidrug resistant bacteria. We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain. Interestingly, by choosing appropriate monomers, these cationic polymers can form core-shell micelles. These polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial species. It is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial activities. Cytotoxicity assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers.http://www.sciencedirect.com/science/article/pii/S2452199X17301214Antimicrobial polymersBile acidQuaternary ammoniumLithocholic acidPolyioneneFacial amphiphilicity |
| spellingShingle | Mitra S. Ganewatta Md Anisur Rahman Louis Mercado Tinom Shokfai Alan W. Decho Theresa M. Reineke Chuanbing Tang Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid Bioactive Materials Antimicrobial polymers Bile acid Quaternary ammonium Lithocholic acid Polyionene Facial amphiphilicity |
| title | Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid |
| title_full | Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid |
| title_fullStr | Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid |
| title_full_unstemmed | Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid |
| title_short | Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid |
| title_sort | facially amphiphilic polyionene biocidal polymers derived from lithocholic acid |
| topic | Antimicrobial polymers Bile acid Quaternary ammonium Lithocholic acid Polyionene Facial amphiphilicity |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X17301214 |
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