The Use of Polymer Blends in the Treatment of Ocular Diseases
The eye is an organ with limited drug access due to its anatomical and physiological barriers, and the usual forms of ocular administration are limited in terms of drug penetration, residence time, and bioavailability, as well as low patient compliance. Hence, therapeutic innovations in new drug del...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/7/1431 |
| _version_ | 1797444369952800768 |
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| author | Raquel Gregorio Arribada Francine Behar-Cohen Andre Luis Branco de Barros Armando Silva-Cunha |
| author_facet | Raquel Gregorio Arribada Francine Behar-Cohen Andre Luis Branco de Barros Armando Silva-Cunha |
| author_sort | Raquel Gregorio Arribada |
| collection | DOAJ |
| description | The eye is an organ with limited drug access due to its anatomical and physiological barriers, and the usual forms of ocular administration are limited in terms of drug penetration, residence time, and bioavailability, as well as low patient compliance. Hence, therapeutic innovations in new drug delivery systems (DDS) have been widely explored since they show numerous advantages over conventional methods, besides delivering the content to the eye without interfering with its normal functioning. Polymers are usually used in DDS and many of them are applicable to ophthalmic use, especially biodegradable ones. Even so, it can be a hard task to find a singular polymer with all the desirable properties to deliver the best performance, and combining two or more polymers in a blend has proven to be more convenient, efficient, and cost-effective. This review was carried out to assess the use of polymer blends as DDS. The search conducted in the databases of Pubmed and Scopus for specific terms revealed that although the physical combination of polymers is largely applied, the term polymer blend still has low compliance. |
| first_indexed | 2024-03-09T13:10:42Z |
| format | Article |
| id | doaj.art-82b7249988624926a02ef3b99efe486b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T13:10:42Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-82b7249988624926a02ef3b99efe486b2023-11-30T21:41:59ZengMDPI AGPharmaceutics1999-49232022-07-01147143110.3390/pharmaceutics14071431The Use of Polymer Blends in the Treatment of Ocular DiseasesRaquel Gregorio Arribada0Francine Behar-Cohen1Andre Luis Branco de Barros2Armando Silva-Cunha3Laboratory of Pharmacotechnics and Pharmaceutical Technology, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, BrazilInserm UMR_S 1138, Team 17, Physiopathology of Ocular Diseases: Therapeutic Innovations at Centre de Recherche des Cordeliers, 75006 Paris, FranceLaboratory of Pharmacotechnics and Pharmaceutical Technology, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, BrazilLaboratory of Pharmacotechnics and Pharmaceutical Technology, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, BrazilThe eye is an organ with limited drug access due to its anatomical and physiological barriers, and the usual forms of ocular administration are limited in terms of drug penetration, residence time, and bioavailability, as well as low patient compliance. Hence, therapeutic innovations in new drug delivery systems (DDS) have been widely explored since they show numerous advantages over conventional methods, besides delivering the content to the eye without interfering with its normal functioning. Polymers are usually used in DDS and many of them are applicable to ophthalmic use, especially biodegradable ones. Even so, it can be a hard task to find a singular polymer with all the desirable properties to deliver the best performance, and combining two or more polymers in a blend has proven to be more convenient, efficient, and cost-effective. This review was carried out to assess the use of polymer blends as DDS. The search conducted in the databases of Pubmed and Scopus for specific terms revealed that although the physical combination of polymers is largely applied, the term polymer blend still has low compliance.https://www.mdpi.com/1999-4923/14/7/1431polymer blendbiopolymersophthalmic administrationdrug delivery systempolymer associationocular use |
| spellingShingle | Raquel Gregorio Arribada Francine Behar-Cohen Andre Luis Branco de Barros Armando Silva-Cunha The Use of Polymer Blends in the Treatment of Ocular Diseases Pharmaceutics polymer blend biopolymers ophthalmic administration drug delivery system polymer association ocular use |
| title | The Use of Polymer Blends in the Treatment of Ocular Diseases |
| title_full | The Use of Polymer Blends in the Treatment of Ocular Diseases |
| title_fullStr | The Use of Polymer Blends in the Treatment of Ocular Diseases |
| title_full_unstemmed | The Use of Polymer Blends in the Treatment of Ocular Diseases |
| title_short | The Use of Polymer Blends in the Treatment of Ocular Diseases |
| title_sort | use of polymer blends in the treatment of ocular diseases |
| topic | polymer blend biopolymers ophthalmic administration drug delivery system polymer association ocular use |
| url | https://www.mdpi.com/1999-4923/14/7/1431 |
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