Targets and Tools: Nucleic Acids for Surface-Enhanced Raman Spectroscopy

Surface-enhanced Raman spectroscopy (SERS) merges nanotechnology with conventional Raman spectroscopy to produce an ultrasensitive and highly specific analytical tool that has been exploited as the optical signal read-out in a variety of advanced applications. In this feature article, we delineate t...

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Main Authors: Irene Calderon, Luca Guerrini, Ramon A. Alvarez-Puebla
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biosensors
Subjects:
Online Access:https://www.mdpi.com/2079-6374/11/7/230
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author Irene Calderon
Luca Guerrini
Ramon A. Alvarez-Puebla
author_facet Irene Calderon
Luca Guerrini
Ramon A. Alvarez-Puebla
author_sort Irene Calderon
collection DOAJ
description Surface-enhanced Raman spectroscopy (SERS) merges nanotechnology with conventional Raman spectroscopy to produce an ultrasensitive and highly specific analytical tool that has been exploited as the optical signal read-out in a variety of advanced applications. In this feature article, we delineate the main features of the intertwined relationship between SERS and nucleic acids (NAs). In particular, we report representative examples of the implementation of SERS in biosensing platforms for NA detection, the integration of DNA as the biorecognition element onto plasmonic materials for SERS analysis of different classes of analytes (from metal ions to microorgniasms) and, finally, the use of structural DNA nanotechnology for the precise engineering of SERS-active nanomaterials.
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spelling doaj.art-82b8da978f7a4307baebfc35e89350bd2023-11-22T03:19:55ZengMDPI AGBiosensors2079-63742021-07-0111723010.3390/bios11070230Targets and Tools: Nucleic Acids for Surface-Enhanced Raman SpectroscopyIrene Calderon0Luca Guerrini1Ramon A. Alvarez-Puebla2Department of Physical and Inorganic Chemistry, Universitat Rovira i Virgili, Carrer de Marcel∙lí Domingo, s/n, 43007 Tarragona, SpainDepartment of Physical and Inorganic Chemistry, Universitat Rovira i Virgili, Carrer de Marcel∙lí Domingo, s/n, 43007 Tarragona, SpainDepartment of Physical and Inorganic Chemistry, Universitat Rovira i Virgili, Carrer de Marcel∙lí Domingo, s/n, 43007 Tarragona, SpainSurface-enhanced Raman spectroscopy (SERS) merges nanotechnology with conventional Raman spectroscopy to produce an ultrasensitive and highly specific analytical tool that has been exploited as the optical signal read-out in a variety of advanced applications. In this feature article, we delineate the main features of the intertwined relationship between SERS and nucleic acids (NAs). In particular, we report representative examples of the implementation of SERS in biosensing platforms for NA detection, the integration of DNA as the biorecognition element onto plasmonic materials for SERS analysis of different classes of analytes (from metal ions to microorgniasms) and, finally, the use of structural DNA nanotechnology for the precise engineering of SERS-active nanomaterials.https://www.mdpi.com/2079-6374/11/7/230surface-enhanced Raman spectroscopyDNAplasmonicsnanoparticlessensing
spellingShingle Irene Calderon
Luca Guerrini
Ramon A. Alvarez-Puebla
Targets and Tools: Nucleic Acids for Surface-Enhanced Raman Spectroscopy
Biosensors
surface-enhanced Raman spectroscopy
DNA
plasmonics
nanoparticles
sensing
title Targets and Tools: Nucleic Acids for Surface-Enhanced Raman Spectroscopy
title_full Targets and Tools: Nucleic Acids for Surface-Enhanced Raman Spectroscopy
title_fullStr Targets and Tools: Nucleic Acids for Surface-Enhanced Raman Spectroscopy
title_full_unstemmed Targets and Tools: Nucleic Acids for Surface-Enhanced Raman Spectroscopy
title_short Targets and Tools: Nucleic Acids for Surface-Enhanced Raman Spectroscopy
title_sort targets and tools nucleic acids for surface enhanced raman spectroscopy
topic surface-enhanced Raman spectroscopy
DNA
plasmonics
nanoparticles
sensing
url https://www.mdpi.com/2079-6374/11/7/230
work_keys_str_mv AT irenecalderon targetsandtoolsnucleicacidsforsurfaceenhancedramanspectroscopy
AT lucaguerrini targetsandtoolsnucleicacidsforsurfaceenhancedramanspectroscopy
AT ramonaalvarezpuebla targetsandtoolsnucleicacidsforsurfaceenhancedramanspectroscopy