A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats
Novel forms of fibrillated cellulose offer improved attributes for use in foods. Conventional cellulose and many of its derivatives are already widely used as food additives and are authorized as safe for use in foods in many countries. However, novel forms have not yet been thoroughly investigated...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
|
| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750019305967 |
| _version_ | 1818448863491522560 |
|---|---|
| author | Kimberly J. Ong James D. Ede Cassidy A. Pomeroy-Carter Christie M. Sayes Marina R. Mulenos Jo Anne Shatkin |
| author_facet | Kimberly J. Ong James D. Ede Cassidy A. Pomeroy-Carter Christie M. Sayes Marina R. Mulenos Jo Anne Shatkin |
| author_sort | Kimberly J. Ong |
| collection | DOAJ |
| description | Novel forms of fibrillated cellulose offer improved attributes for use in foods. Conventional cellulose and many of its derivatives are already widely used as food additives and are authorized as safe for use in foods in many countries. However, novel forms have not yet been thoroughly investigated using standardized testing methods. This study assesses the 90-day dietary toxicity of fibrillated cellulose, as compared to a conventional cellulose, Solka Floc. Sprague Dawley rats were fed 2 %, 3 %, or 4 % fibrillated cellulose for 90 consecutive days, and parallel Solka Floc groups were used as controls. Survival, clinical observations, body weight, food consumption, ophthalmologic evaluations, hematology, serum chemistry, urinalysis, post-mortem anatomic pathology, and histopathology were monitored and performed. No adverse observations were noted in relation to the administration of fibrillated cellulose. Under the conditions of this study and based on the toxicological endpoints evaluated, the no-observed-adverse-effect level (NOAEL) for fibrillated cellulose was 2194.2 mg/kg/day (males) and 2666.6 mg/kg/day (females), corresponding to the highest dose tested (4 %) for male and female Sprague Dawley rats. These results demonstrate that fibrillated cellulose behaves similarly to conventional cellulose and raises no safety concerns when used as a food ingredient at these concentrations. |
| first_indexed | 2024-12-14T20:26:16Z |
| format | Article |
| id | doaj.art-82b96befa41a4dfc920c977ab7581c7a |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-14T20:26:16Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-82b96befa41a4dfc920c977ab7581c7a2022-12-21T22:48:37ZengElsevierToxicology Reports2214-75002020-01-017174182A 90-day dietary study with fibrillated cellulose in Sprague-Dawley ratsKimberly J. Ong0James D. Ede1Cassidy A. Pomeroy-Carter2Christie M. Sayes3Marina R. Mulenos4Jo Anne Shatkin5Vireo Advisors, LLC, Boston, MA 02130-4323, United StatesVireo Advisors, LLC, Boston, MA 02130-4323, United StatesVireo Advisors, LLC, Boston, MA 02130-4323, United StatesBaylor University, Department of Environmental Science, One Bear Place #97266, Waco, TX 76798- 7266, United StatesBaylor University, Department of Environmental Science, One Bear Place #97266, Waco, TX 76798- 7266, United StatesVireo Advisors, LLC, Boston, MA 02130-4323, United States; Corresponding author.Novel forms of fibrillated cellulose offer improved attributes for use in foods. Conventional cellulose and many of its derivatives are already widely used as food additives and are authorized as safe for use in foods in many countries. However, novel forms have not yet been thoroughly investigated using standardized testing methods. This study assesses the 90-day dietary toxicity of fibrillated cellulose, as compared to a conventional cellulose, Solka Floc. Sprague Dawley rats were fed 2 %, 3 %, or 4 % fibrillated cellulose for 90 consecutive days, and parallel Solka Floc groups were used as controls. Survival, clinical observations, body weight, food consumption, ophthalmologic evaluations, hematology, serum chemistry, urinalysis, post-mortem anatomic pathology, and histopathology were monitored and performed. No adverse observations were noted in relation to the administration of fibrillated cellulose. Under the conditions of this study and based on the toxicological endpoints evaluated, the no-observed-adverse-effect level (NOAEL) for fibrillated cellulose was 2194.2 mg/kg/day (males) and 2666.6 mg/kg/day (females), corresponding to the highest dose tested (4 %) for male and female Sprague Dawley rats. These results demonstrate that fibrillated cellulose behaves similarly to conventional cellulose and raises no safety concerns when used as a food ingredient at these concentrations.http://www.sciencedirect.com/science/article/pii/S2214750019305967CelluloseFibrillated cellulose90-day subchronic studyOECD 408Oral exposureNOAEL |
| spellingShingle | Kimberly J. Ong James D. Ede Cassidy A. Pomeroy-Carter Christie M. Sayes Marina R. Mulenos Jo Anne Shatkin A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats Toxicology Reports Cellulose Fibrillated cellulose 90-day subchronic study OECD 408 Oral exposure NOAEL |
| title | A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats |
| title_full | A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats |
| title_fullStr | A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats |
| title_full_unstemmed | A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats |
| title_short | A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats |
| title_sort | 90 day dietary study with fibrillated cellulose in sprague dawley rats |
| topic | Cellulose Fibrillated cellulose 90-day subchronic study OECD 408 Oral exposure NOAEL |
| url | http://www.sciencedirect.com/science/article/pii/S2214750019305967 |
| work_keys_str_mv | AT kimberlyjong a90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats AT jamesdede a90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats AT cassidyapomeroycarter a90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats AT christiemsayes a90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats AT marinarmulenos a90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats AT joanneshatkin a90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats AT kimberlyjong 90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats AT jamesdede 90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats AT cassidyapomeroycarter 90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats AT christiemsayes 90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats AT marinarmulenos 90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats AT joanneshatkin 90daydietarystudywithfibrillatedcelluloseinspraguedawleyrats |