Prevalence and incidence rate of tuberculosis among HIV-infected patients enrolled in HIV care, treatment, and support program in mainland Tanzania
Abstract Background Despite improvements in access to antiretroviral therapy (ART), mortality in people living with human immunodeficiency virus (PLHIV) is still high and primarily attributed to tuberculosis (TB) infection. In Sub-Saharan Africa, approximately 80% of HIV-related mortality cases are...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | Tropical Medicine and Health |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41182-020-00264-1 |
| _version_ | 1819091728147152896 |
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| author | M. Majigo G. Somi A. Joachim J. Manyahi J. Nondi V. Sambu A. Rwebembera N. Makyao A. Ramadhani W. Maokola J. Todd M. I. Matee |
| author_facet | M. Majigo G. Somi A. Joachim J. Manyahi J. Nondi V. Sambu A. Rwebembera N. Makyao A. Ramadhani W. Maokola J. Todd M. I. Matee |
| author_sort | M. Majigo |
| collection | DOAJ |
| description | Abstract Background Despite improvements in access to antiretroviral therapy (ART), mortality in people living with human immunodeficiency virus (PLHIV) is still high and primarily attributed to tuberculosis (TB) infection. In Sub-Saharan Africa, approximately 80% of HIV-related mortality cases are associated with TB. Relatively little is known about the incidence of TB among PLHIV in Tanzania and the determinant factors. We report the prevalence and incidence rate of confirmed TB and determine association with selected demographic and program-related factors based on data in the national HIV care and treatment program from 2011 to 2014. Methods We used the Tanzania National AIDS Control Programme database to obtain information on all HIV clients enrolled in the HIV care and treatment program between January 2011 and December 2014. We analyzed retrospective cohort data to assess the prevalence and TB incidence rate per 1000 person-years. A multivariable Cox proportional hazards regression model was used to estimate hazard ratios and 95% confidence intervals for putatively associated factors. Results Over 4 years, there were 22,071 confirmed cases of pulmonary TB in 1,323,600 person-years. The overall TB incidence was around 16.7 (95% CI 16.4–16.9) cases per 1000 person-years. The annual incidence rate decreased by 12.4 % from 17.0 (95% CI 16.5–17.4) in 2011 to 14.9 (95% CI 14.5–15.4) in 2014. The TB incidence rate was higher in persons not using ART and in males than in females. The incidence of TB was higher in patients with advanced HIV disease and decreased with increasing age. The overall prevalence of TB was 2.2%, with a peak prevalence of 2.5% in 2013 and was higher among children < 15 years (3.2%) in the same year. Conclusion The study found an overall decrease in the incidence of TB in PLHIV. Our results emphasize the need for early initiation of ART and the provision of TB preventive therapy for those PLHIV without active TB after intensified TB case-finding. |
| first_indexed | 2024-12-21T22:44:20Z |
| format | Article |
| id | doaj.art-82bb1ca9415e45de82b335f422f2290b |
| institution | Directory Open Access Journal |
| issn | 1349-4147 |
| language | English |
| last_indexed | 2024-12-21T22:44:20Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Tropical Medicine and Health |
| spelling | doaj.art-82bb1ca9415e45de82b335f422f2290b2022-12-21T18:47:45ZengBMCTropical Medicine and Health1349-41472020-09-014811810.1186/s41182-020-00264-1Prevalence and incidence rate of tuberculosis among HIV-infected patients enrolled in HIV care, treatment, and support program in mainland TanzaniaM. Majigo0G. Somi1A. Joachim2J. Manyahi3J. Nondi4V. Sambu5A. Rwebembera6N. Makyao7A. Ramadhani8W. Maokola9J. Todd10M. I. Matee11Department of Microbiology and Immunology, School of Medicine, Muhimbili University of Health and Allied SciencesNational AIDS Control Programme, Ministry of Health, Community Development, Gender, Elderly and ChildrenDepartment of Microbiology and Immunology, School of Medicine, Muhimbili University of Health and Allied SciencesDepartment of Microbiology and Immunology, School of Medicine, Muhimbili University of Health and Allied SciencesNational AIDS Control Programme, Ministry of Health, Community Development, Gender, Elderly and ChildrenNational AIDS Control Programme, Ministry of Health, Community Development, Gender, Elderly and ChildrenNational AIDS Control Programme, Ministry of Health, Community Development, Gender, Elderly and ChildrenNational AIDS Control Programme, Ministry of Health, Community Development, Gender, Elderly and ChildrenNational AIDS Control Programme, Ministry of Health, Community Development, Gender, Elderly and ChildrenNational AIDS Control Programme, Ministry of Health, Community Development, Gender, Elderly and ChildrenLondon School of Hygiene and Tropical Medicine and National Institute for Medical ResearchDepartment of Microbiology and Immunology, School of Medicine, Muhimbili University of Health and Allied SciencesAbstract Background Despite improvements in access to antiretroviral therapy (ART), mortality in people living with human immunodeficiency virus (PLHIV) is still high and primarily attributed to tuberculosis (TB) infection. In Sub-Saharan Africa, approximately 80% of HIV-related mortality cases are associated with TB. Relatively little is known about the incidence of TB among PLHIV in Tanzania and the determinant factors. We report the prevalence and incidence rate of confirmed TB and determine association with selected demographic and program-related factors based on data in the national HIV care and treatment program from 2011 to 2014. Methods We used the Tanzania National AIDS Control Programme database to obtain information on all HIV clients enrolled in the HIV care and treatment program between January 2011 and December 2014. We analyzed retrospective cohort data to assess the prevalence and TB incidence rate per 1000 person-years. A multivariable Cox proportional hazards regression model was used to estimate hazard ratios and 95% confidence intervals for putatively associated factors. Results Over 4 years, there were 22,071 confirmed cases of pulmonary TB in 1,323,600 person-years. The overall TB incidence was around 16.7 (95% CI 16.4–16.9) cases per 1000 person-years. The annual incidence rate decreased by 12.4 % from 17.0 (95% CI 16.5–17.4) in 2011 to 14.9 (95% CI 14.5–15.4) in 2014. The TB incidence rate was higher in persons not using ART and in males than in females. The incidence of TB was higher in patients with advanced HIV disease and decreased with increasing age. The overall prevalence of TB was 2.2%, with a peak prevalence of 2.5% in 2013 and was higher among children < 15 years (3.2%) in the same year. Conclusion The study found an overall decrease in the incidence of TB in PLHIV. Our results emphasize the need for early initiation of ART and the provision of TB preventive therapy for those PLHIV without active TB after intensified TB case-finding.http://link.springer.com/article/10.1186/s41182-020-00264-1TuberculosisHIVIncidence of tuberculosisAntiretroviral therapyCollaborative TB/HIV |
| spellingShingle | M. Majigo G. Somi A. Joachim J. Manyahi J. Nondi V. Sambu A. Rwebembera N. Makyao A. Ramadhani W. Maokola J. Todd M. I. Matee Prevalence and incidence rate of tuberculosis among HIV-infected patients enrolled in HIV care, treatment, and support program in mainland Tanzania Tropical Medicine and Health Tuberculosis HIV Incidence of tuberculosis Antiretroviral therapy Collaborative TB/HIV |
| title | Prevalence and incidence rate of tuberculosis among HIV-infected patients enrolled in HIV care, treatment, and support program in mainland Tanzania |
| title_full | Prevalence and incidence rate of tuberculosis among HIV-infected patients enrolled in HIV care, treatment, and support program in mainland Tanzania |
| title_fullStr | Prevalence and incidence rate of tuberculosis among HIV-infected patients enrolled in HIV care, treatment, and support program in mainland Tanzania |
| title_full_unstemmed | Prevalence and incidence rate of tuberculosis among HIV-infected patients enrolled in HIV care, treatment, and support program in mainland Tanzania |
| title_short | Prevalence and incidence rate of tuberculosis among HIV-infected patients enrolled in HIV care, treatment, and support program in mainland Tanzania |
| title_sort | prevalence and incidence rate of tuberculosis among hiv infected patients enrolled in hiv care treatment and support program in mainland tanzania |
| topic | Tuberculosis HIV Incidence of tuberculosis Antiretroviral therapy Collaborative TB/HIV |
| url | http://link.springer.com/article/10.1186/s41182-020-00264-1 |
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