Vaccinations and Immune Response in Celiac Disease
Immune response to vaccinations in celiac patients is of growing scientific interest. However, some aspects of the relationship between celiac disease (CD) and vaccines are still unclear. A comprehensive search of published literature using the PubMed database was carried out using the following key...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/8/2/278 |
| _version_ | 1797566022628147200 |
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| author | Stefano Passanisi Valeria Dipasquale Claudio Romano |
| author_facet | Stefano Passanisi Valeria Dipasquale Claudio Romano |
| author_sort | Stefano Passanisi |
| collection | DOAJ |
| description | Immune response to vaccinations in celiac patients is of growing scientific interest. However, some aspects of the relationship between celiac disease (CD) and vaccines are still unclear. A comprehensive search of published literature using the PubMed database was carried out using the following key terms: “adaptive immunity”, “celiac disease”, “humoral immune response”, “immunization”, and “vaccination”. To date, there is no evidence showing any causative association between vaccines and CD development. Therefore, vaccinations may be administered according to the modalities and timing of the National Immunization Schedule for each country. The rotavirus vaccine is currently recommended for the general population, and according to some data, it appears to reduce the risk for the development of CD autoimmunity in the early years of life. Regarding the hepatitis B virus, a booster dose of the vaccine is often required due to the low or the lost immune response rate in CD. Furthermore, determination of hepatitis B antibody titers could be useful in newly diagnosed CD subjects regardless of age at diagnosis. Finally, pneumococcal vaccines may be administered in patients with advancing age at diagnosis and concomitant risk factors. Future clinical practice guidelines for vaccination and monitoring programs in celiac patients could be recommended. |
| first_indexed | 2024-03-10T19:20:58Z |
| format | Article |
| id | doaj.art-82bd0acd0b3449b4aac38a8f4b41ed84 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T19:20:58Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-82bd0acd0b3449b4aac38a8f4b41ed842023-11-20T02:58:05ZengMDPI AGVaccines2076-393X2020-06-018227810.3390/vaccines8020278Vaccinations and Immune Response in Celiac DiseaseStefano Passanisi0Valeria Dipasquale1Claudio Romano2Paediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98124 Messina, ItalyPaediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98124 Messina, ItalyPaediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98124 Messina, ItalyImmune response to vaccinations in celiac patients is of growing scientific interest. However, some aspects of the relationship between celiac disease (CD) and vaccines are still unclear. A comprehensive search of published literature using the PubMed database was carried out using the following key terms: “adaptive immunity”, “celiac disease”, “humoral immune response”, “immunization”, and “vaccination”. To date, there is no evidence showing any causative association between vaccines and CD development. Therefore, vaccinations may be administered according to the modalities and timing of the National Immunization Schedule for each country. The rotavirus vaccine is currently recommended for the general population, and according to some data, it appears to reduce the risk for the development of CD autoimmunity in the early years of life. Regarding the hepatitis B virus, a booster dose of the vaccine is often required due to the low or the lost immune response rate in CD. Furthermore, determination of hepatitis B antibody titers could be useful in newly diagnosed CD subjects regardless of age at diagnosis. Finally, pneumococcal vaccines may be administered in patients with advancing age at diagnosis and concomitant risk factors. Future clinical practice guidelines for vaccination and monitoring programs in celiac patients could be recommended.https://www.mdpi.com/2076-393X/8/2/278adaptive immunitychildrenhepatitis Bimmunogenicitypneumococcusrevaccination |
| spellingShingle | Stefano Passanisi Valeria Dipasquale Claudio Romano Vaccinations and Immune Response in Celiac Disease Vaccines adaptive immunity children hepatitis B immunogenicity pneumococcus revaccination |
| title | Vaccinations and Immune Response in Celiac Disease |
| title_full | Vaccinations and Immune Response in Celiac Disease |
| title_fullStr | Vaccinations and Immune Response in Celiac Disease |
| title_full_unstemmed | Vaccinations and Immune Response in Celiac Disease |
| title_short | Vaccinations and Immune Response in Celiac Disease |
| title_sort | vaccinations and immune response in celiac disease |
| topic | adaptive immunity children hepatitis B immunogenicity pneumococcus revaccination |
| url | https://www.mdpi.com/2076-393X/8/2/278 |
| work_keys_str_mv | AT stefanopassanisi vaccinationsandimmuneresponseinceliacdisease AT valeriadipasquale vaccinationsandimmuneresponseinceliacdisease AT claudioromano vaccinationsandimmuneresponseinceliacdisease |