Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN
Neurons in the dorsolateral geniculate nucleus (dLGN) of the thalamus receive a substantial proportion of modulatory inputs from corticothalamic (CT) feedback and brain stem nuclei. Hypothesizing that these modulatory influences might be differentially engaged depending on the visual stimulus and be...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/70469 |
| _version_ | 1811203330768109568 |
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| author | Martin A Spacek Davide Crombie Yannik Bauer Gregory Born Xinyu Liu Steffen Katzner Laura Busse |
| author_facet | Martin A Spacek Davide Crombie Yannik Bauer Gregory Born Xinyu Liu Steffen Katzner Laura Busse |
| author_sort | Martin A Spacek |
| collection | DOAJ |
| description | Neurons in the dorsolateral geniculate nucleus (dLGN) of the thalamus receive a substantial proportion of modulatory inputs from corticothalamic (CT) feedback and brain stem nuclei. Hypothesizing that these modulatory influences might be differentially engaged depending on the visual stimulus and behavioral state, we performed in vivo extracellular recordings from mouse dLGN while optogenetically suppressing CT feedback and monitoring behavioral state by locomotion and pupil dilation. For naturalistic movie clips, we found CT feedback to consistently increase dLGN response gain and promote tonic firing. In contrast, for gratings, CT feedback effects on firing rates were mixed. For both stimulus types, the neural signatures of CT feedback closely resembled those of behavioral state, yet effects of behavioral state on responses to movies persisted even when CT feedback was suppressed. We conclude that CT feedback modulates visual information on its way to cortex in a stimulus-dependent manner, but largely independently of behavioral state. |
| first_indexed | 2024-04-12T02:54:00Z |
| format | Article |
| id | doaj.art-82bd0d9b23ef432dace2f65f57179ec3 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:54:00Z |
| publishDate | 2022-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-82bd0d9b23ef432dace2f65f57179ec32022-12-22T03:50:53ZengeLife Sciences Publications LtdeLife2050-084X2022-03-011110.7554/eLife.70469Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGNMartin A Spacek0https://orcid.org/0000-0002-9519-3284Davide Crombie1Yannik Bauer2https://orcid.org/0000-0003-2613-6443Gregory Born3https://orcid.org/0000-0003-0430-3052Xinyu Liu4Steffen Katzner5https://orcid.org/0000-0002-4424-2197Laura Busse6https://orcid.org/0000-0002-6127-7754Division of Neurobiology, Faculty of Biology, LMU Munich, Planegg-Martinsried, GermanyDivision of Neurobiology, Faculty of Biology, LMU Munich, Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences, LMU Munich, Munich, GermanyDivision of Neurobiology, Faculty of Biology, LMU Munich, Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences, LMU Munich, Munich, GermanyDivision of Neurobiology, Faculty of Biology, LMU Munich, Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences, LMU Munich, Munich, GermanyDivision of Neurobiology, Faculty of Biology, LMU Munich, Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences, LMU Munich, Munich, GermanyDivision of Neurobiology, Faculty of Biology, LMU Munich, Planegg-Martinsried, GermanyDivision of Neurobiology, Faculty of Biology, LMU Munich, Planegg-Martinsried, Germany; Bernstein Centre for Computational Neuroscience, Munich, GermanyNeurons in the dorsolateral geniculate nucleus (dLGN) of the thalamus receive a substantial proportion of modulatory inputs from corticothalamic (CT) feedback and brain stem nuclei. Hypothesizing that these modulatory influences might be differentially engaged depending on the visual stimulus and behavioral state, we performed in vivo extracellular recordings from mouse dLGN while optogenetically suppressing CT feedback and monitoring behavioral state by locomotion and pupil dilation. For naturalistic movie clips, we found CT feedback to consistently increase dLGN response gain and promote tonic firing. In contrast, for gratings, CT feedback effects on firing rates were mixed. For both stimulus types, the neural signatures of CT feedback closely resembled those of behavioral state, yet effects of behavioral state on responses to movies persisted even when CT feedback was suppressed. We conclude that CT feedback modulates visual information on its way to cortex in a stimulus-dependent manner, but largely independently of behavioral state.https://elifesciences.org/articles/70469lateral geniculate nucleuscorticothalamic feedbacknaturalistic movieslocomotionpupil dilationfiring mode |
| spellingShingle | Martin A Spacek Davide Crombie Yannik Bauer Gregory Born Xinyu Liu Steffen Katzner Laura Busse Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN eLife lateral geniculate nucleus corticothalamic feedback naturalistic movies locomotion pupil dilation firing mode |
| title | Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN |
| title_full | Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN |
| title_fullStr | Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN |
| title_full_unstemmed | Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN |
| title_short | Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN |
| title_sort | robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dlgn |
| topic | lateral geniculate nucleus corticothalamic feedback naturalistic movies locomotion pupil dilation firing mode |
| url | https://elifesciences.org/articles/70469 |
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